MolNFT v1 · #104203 · protein
The crystal structure of NHERF1 PDZ2 CXCR2 complex revealed by the NHERF1 CXCR2 chimeric protein
4Q3H · NA(+)/H(+) exchange regulatory cofactor nhe-RF1: “The crystal structure of NHERF1 PDZ2 CXCR2 complex revealed by the NHERF1 CXCR2 chimeric protein”. X-ray diffraction, 2 pockets (best druggability 0.32). MolNFT v1 #104203 on…
- PDB
- 4Q3H
- Type
- protein
- Length
- 180 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NA(+)/H(+) exchange regulatory cofactor nhe-RF1
- UniProt
- O14745, P25025
- Pockets
- 2 · best druggability 0.32
Structure
x-ray diffraction · 1 distinct chain · 16% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | NA(+)/H(+) exchange regulatory cofactor nhe-RF1 | protein | 90 | 16% helix, 37% strand | O14745, P25025 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 64 | 0.32 | 0.75 | 12 | empty |
| 2 | 67 | 0.29 | 0.73 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 326 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 4Q3H · The crystal structure of NHERF1 PDZ2 CXCR2 complex revealed by the NHERF1 CXCR2 chimeric… · the same entry in another collection · chain A against A, TM-score 1.00
- O14745 · AlphaFold monomer V2.0 prediction for NA(+)/H(+) exchange regulatory cofactor nhe-RF1… · a predicted model of the same protein · chain A against A, TM-score 0.91
- P25025 · AlphaFold monomer V2.0 prediction for C-X-C chemokine receptor type 2 (P25025) · a predicted model of the same protein · chain A against A, TM-score 0.29
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14745
- Every structure of UniProt P25025
- Elsewhere: RCSB PDB 4Q3H · PDBe 4Q3H · UniProt O14745 · UniProt P25025
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