Research workbench
The crystal structure of NHERF1 PDZ2 CXCR2 complex revealed by the NHERF1 CXCR2 chimeric protein
Analyse The crystal structure of NHERF1 PDZ2 CXCR2 complex revealed by the NHERF1 CXCR2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4Q3H
- Type
- protein
- Length
- 180 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NA(+)/H(+) exchange regulatory cofactor nhe-RF1
- UniProt
- O14745, P25025
- Pockets
- 2 · best druggability 0.32
Structure
x-ray diffraction · 1 distinct chain · 16% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | NA(+)/H(+) exchange regulatory cofactor nhe-RF1 | protein | 90 | 16% helix, 37% strand | O14745, P25025 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 64 | 0.32 | 0.75 | 12 | empty |
| 2 | 67 | 0.29 | 0.73 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 326 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 4Q3H · The crystal structure of NHERF1 PDZ2 CXCR2 complex revealed by the NHERF1 CXCR2 chimeric… · the same entry in another collection · chain A against A, TM-score 1.00
- O14745 · AlphaFold monomer V2.0 prediction for NA(+)/H(+) exchange regulatory cofactor nhe-RF1… · a predicted model of the same protein · chain A against A, TM-score 0.91
- P25025 · AlphaFold monomer V2.0 prediction for C-X-C chemokine receptor type 2 (P25025) · a predicted model of the same protein · chain A against A, TM-score 0.29
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14745
- Every structure of UniProt P25025
- Elsewhere: RCSB PDB 4Q3H · PDBe 4Q3H · UniProt O14745 · UniProt P25025
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.