MolNFT v1 · #7543 · protein

First PDZ domain of the human NA+/H+ exchanger regulatory factor

1G9O · Nhe-rf: “First PDZ domain of the human NA+/H+ exchanger regulatory factor”. X-ray diffraction, 1 pocket (best druggability 0.38). MolNFT v1 #7543 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1G9O
Type: protein
Length: 91 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nhe-rf
UniProt: O14745
Pockets: 1 · best druggability 0.38

Structure

x-ray diffraction · 1 distinct chain · 14% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nhe-rf	protein	91	14% helix, 36% strand	O14745

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	72	0.38	0.78	12	empty

Compared structures

1G9O · First PDZ domain of the human NA+/H+ exchanger regulatory factor · the same entry in another collection · chain A against A, TM-score 1.00
O14745 · AlphaFold monomer V2.0 prediction for NA(+)/H(+) exchange regulatory cofactor nhe-RF1… · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14745
Elsewhere: RCSB PDB 1G9O · PDBe 1G9O · UniProt O14745

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