MolNFT v1 · #103780 · protein

Crystal structure of phospholipase C beta 3 in complex with PDZ1 of NHERF1

4PQW · NA(+)/H(+) exchange regulatory cofactor nhe-RF1: “Crystal structure of phospholipase C beta 3 in complex with PDZ1 of NHERF1”. X-ray diffraction, 2 ligands (NI, CL), 1 pocket (best druggability 0.32). MolNFT v1 #103780 on GenesisL1…

PDB: 4PQW
Type: protein
Length: 91 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: NA(+)/H(+) exchange regulatory cofactor nhe-RF1
UniProt: O14745
Ligands: NI, CL
Pockets: 1 · best druggability 0.32

Structure

x-ray diffraction · 1 distinct chain · 18% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	NA(+)/H(+) exchange regulatory cofactor nhe-RF1	protein	91	18% helix, 33% strand	O14745

Ligands and binding sites

NI · Nickel (II) ion · metal · chains A
CL · Chloride ion · ion · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	58	0.32	0.76	13	empty

Compared structures

4PQW · Crystal Structure of Phospholipase C beta 3 in Complex with PDZ1 of NHERF1 · the same entry in another collection · chain A against A, TM-score 1.00
O14745 · AlphaFold monomer V2.0 prediction for NA(+)/H(+) exchange regulatory cofactor nhe-RF1… · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14745
Elsewhere: RCSB PDB 4PQW · PDBe 4PQW · UniProt O14745

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