UniProt F7X6I3
Bifunctional protein PutA (F7X6I3)
Bifunctional protein PutA (UniProt F7X6I3), EC 1.2.1.88, 1.5.5.2: 49 experimental structures on GenesisL1, 38 ligands bound, 599 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- F7X6I3
- Protein
- Bifunctional protein PutA
- EC
- 1.2.1.88, 1.5.5.2
- Experimental structures
- 49
- Predicted models
- 0
- Ligands
- 38
- Pockets
- 599 · 35 records with a druggable one
Structures
49 records of F7X6I3 in the MolNFT archive: 49 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5KF6 | Structure of proline utilization A from Sinorhizobium meliloti complexed with L-tetrahydrofuroic… | x-ray diffraction | A, B | FAD, NAD, TFB | — |
| 5KF6 | Structure of proline utilization a from sinorhizobium meliloti complexed with L-tetrahydrofuroic… | x-ray diffraction | A, B | FAD, NAD, TFB | — |
| 5KF7 | Structure of proline utilization A from Sinorhizobium meliloti complexed with L-tetrahydrofuroic… | x-ray diffraction | A | FAD, NAD, TFB, SO4, MG | 16 (best 0.87) |
| 5KF7 | Structure of proline utilization a from sinorhizobium meliloti complexed with L-tetrahydrofuroic… | x-ray diffraction | A | FAD, NAD, TFB, SO4 | — |
| 6UFP | Structure of proline utilization A with the FAD covalently modified by L-thiazolidine-2-carboxylate… | x-ray diffraction | A, B | FDA, T2C, NAD, SO4 | 20 (best 0.86) |
| 6UFP | Structure of proline utilization a with the FAD covalently modified by L-thiazolidine-2-carboxylate… | x-ray diffraction | A, B | FDA, T2C, NAD, SO4 | — |
| 6VZ9 | Structure of proline utilization A with the FAD covalently modified by L-thiazolidine-2-carboxylate | x-ray diffraction | A, B | FAD, NAD, MG, T2C, SO4 | 20 (best 0.87) |
| 6VZ9 | Structure of proline utilization a with the FAD covalently modified by L-thiazolidine-2-carboxylate | x-ray diffraction | A, B | FAD, NAD, T2C, SO4 | — |
| 6X99 | Structure of proline utilization A with D-proline bound in the L-glutamate-gamma-semialdehyde… | x-ray diffraction | A, B | FAD, SO4, DPR | 20 (best 0.87) |
| 6X99 | Structure of proline utilization a with D-proline bound in the L- glutamate-gamma-semialdehyde… | x-ray diffraction | A, B | FAD, SO4 | — |
| 6X9A | Structure of proline utilization A with trans-4-hydroxy-D-proline bound in the… | x-ray diffraction | A, B | FAD, UY7, SO4 | 20 (best 0.87) |
| 6X9A | Structure of proline utilization a with trans-4-hydroxy-D-proline bound in the… | x-ray diffraction | A, B | FAD, SO4 | — |
| 6X9B | Structure of proline utilization A with cis-4-hydroxy-D-proline bound in the… | x-ray diffraction | A, B | FAD, NAD, SO4, UYA | 20 (best 0.87) |
| 6X9B | Structure of proline utilization a with cis-4-hydroxy-D-proline bound in the… | x-ray diffraction | A, B | FAD, NAD, SO4 | — |
| 6X9C | Structure of proline utilization A with L-proline bound in the L-glutamate-gamma-semialdehyde… | x-ray diffraction | A, B | NAI, FDA, SO4, MG, PRO | 20 (best 0.84) |
| 6X9C | Structure of proline utilization a with L-proline bound in the L- glutamate-gamma-semialdehyde… | x-ray diffraction | A, B | NAI, FDA, SO4 | — |
| 6X9D | Structure of proline utilization A with trans-4-hydroxy-L-proline bound in the… | x-ray diffraction | A, B | FAD, HYP, NAD, SO4, MG | 20 (best 0.87) |
| 6X9D | Structure of proline utilization a with trans-4-hydroxy-L-proline bound in the… | x-ray diffraction | A, B | FAD, NAD, SO4 | — |
| 7MY9 | Structure of proline utilization A with 1,3-dithiolane-2-carboxylate bound in the proline… | x-ray diffraction | A, B | UJD, FAD, NAD, SO4, MG | 20 (best 0.87) |
| 7MY9 | Structure of proline utilization a with 1,3-dithiolane-2-carboxylate bound in the proline… | x-ray diffraction | A, B | UJD, FAD, NAD, SO4 | — |
| 7MYA | Structure of proline utilization A with the FAD covalently-modified by 1,3-dithiolane | x-ray diffraction | A, B | UJJ, MG, NAD, SO4 | 20 (best 0.86) |
| 7MYA | Structure of proline utilization a with the FAD covalently-modified by 1,3-dithiolane | x-ray diffraction | A, B | UJJ, NAD, SO4 | — |
| 7MYB | Structure of proline utilization A with tetrahydrothiophene-2-carboxylate bound in the proline… | x-ray diffraction | A, B | UJM, UJP, FAD, NAD, SO4, MG | 20 (best 0.88) |
| 7MYB | Structure of proline utilization a with tetrahydrothiophene-2- carboxylate bound in the proline… | x-ray diffraction | A, B | UJM, UJP, FAD, NAD, SO4 | — |
| 7MYC | Structure of proline utilization A with the FAD covalently modified by tetrahydrothiophene | x-ray diffraction | A, B | UJG, NAI, SO4 | 20 (best 0.86) |
| 7MYC | Structure of proline utilization a with the FAD covalently modified by tetrahydrothiophene | x-ray diffraction | A, B | UJG, NAI, SO4 | — |
| 8DKO | Minimal PutA proline dehydrogenase domain (design #1) complexed with S-(-)-tetrahydro-2-furoic acid | x-ray diffraction | A, B | FAD, TFB | 11 (best 0.83) |
| 8DKP | Minimal PutA proline dehydrogenase domain (design #2) complexed with S-(-)-tetrahydro-2-furoic acid | x-ray diffraction | A, B | FAD, TFB | 8 (best 0.84) |
| 8DKQ | Minimal PutA proline dehydrogenase domain (design #2) complexed with 2-(Furan-2-yl)acetic acid | x-ray diffraction | A, B | FAD, SJU | 9 (best 0.84) |
| 8UPZ | Minimal PutA proline dehydrogenase domain (design #2) complexed with (Prop-2-ynylthio)acetic acid | x-ray diffraction | A, B | FAD, X79 | 8 (best 0.84) |
| 8UQ0 | Minimal PutA proline dehydrogenase domain (design #2) complexed with 2-(Cyanomethylthio)acetic acid | x-ray diffraction | A, B | FAD, X7K | 9 (best 0.84) |
| 8UQ1 | Minimal PutA proline dehydrogenase domain (design #2) complexed with (Allylthio)acetic acid | x-ray diffraction | A, B | FAD, X7Q | 10 (best 0.84) |
| 8W0K | Minimal PutA proline dehydrogenase domain (design #2) complexed with 1-hydroxyethane-1-sulfonate | x-ray diffraction | A, B | FAD, GHO | 9 (best 0.81) |
| 9C8A | Minimal PutA proline dehydrogenase domain (design #2) with the FAD N5 modified with propanal… | x-ray diffraction | A, B | FDA, FAD, CBG | 10 (best 0.83) |
| 9C8B | Minimal PutA proline dehydrogenase domain (design #2) with the FAD N5 modified with propanal… | x-ray diffraction | A, B | FDA, FAD, CBG | 9 (best 0.83) |
| 9C8C | Structure of proline utilization A with the FAD covalently-modified by propanal resulting from… | x-ray diffraction | A, B | FDA, CBG, NAD, MG, SO4, A1AV8 | 20 (best 0.84) |
| 9DL2 | Structure of proline utilization A complexed with 2,3-dihydro-1,4-benzodioxine-5-carboxylic acid | x-ray diffraction | A, B | FAD, 53E, NAD, SO4, MG | 20 (best 0.87) |
| 9DL3 | Structure of proline utilization A complexed with quinoline-2-carboxylic acid | x-ray diffraction | A, B | FAD, QNC, SO4, MG | 20 (best 0.85) |
| 9DL4 | Structure of proline utilization A complexed with 2-pyridinethiol | x-ray diffraction | A, B | PYS, SO4, FAD | 20 (best 0.84) |
| 9DL5 | Structure of proline utilization A complexed with 5-chloro-1-inda | x-ray diffraction | A, B | FAD, A1BDA, SO4 | 20 (best 0.84) |
| 9DL6 | Structure of proline utilization A complexed with piperidine-3-carboxylic acid | x-ray diffraction | A, B | FAD, A1BDB, ID7, SO4, NAD, MG | 20 (best 0.86) |
| 9DL7 | Structure of proline utilization A complexed with 1-(4-fluorophenyl)thiourea | x-ray diffraction | A, B | FAD, 8P4, SO4 | 20 (best 0.85) |
| 9DL8 | Structure of proline utilization A soaked with 4-methoxybenzyl alcohol | x-ray diffraction | A, B | FAD, A1BDD, NAD, SO4 | 20 (best 0.86) |
| 9DL9 | Structure of proline utilization A co-crystallized with 4-methoxybenzyl alcohol | x-ray diffraction | A, B | FAD, A1BDD, NAD, SO4, MG | 20 (best 0.87) |
| 9E0A | Structure of proline utilization A complexed with 1,4-benzenedimethanol | x-ray diffraction | A, B | FAD, NAD, SO4, MG, A1BDW | 20 (best 0.87) |
| 9E0B | Structure of proline utilization A complexed with (2,3-dihydro-1-benzofuran-5-yl)methanol | x-ray diffraction | A, B | FAD, A1AQC, NAD, SO4, MG | 20 (best 0.87) |
| 9E0C | Structure of proline utilization A complexed with 1-benzofuran-5-ylmethanol | x-ray diffraction | A, B | FAD, A1BDX, NAD, SO4, MG | 20 (best 0.87) |
| 9E0D | Structure of proline utilization A complexed with piperonyl alcohol | x-ray diffraction | A, B | FAD, A1BDV, NAD, SO4, MG | 20 (best 0.87) |
| 9E0E | Structure of proline utilization A complexed with (1H-indol-5-yl)methanol | x-ray diffraction | A, B | FAD, A1BDU, NAD, SO4, MG | 20 (best 0.87) |
Ligands
- FAD · Flavin-adenine dinucleotide · in 40 records
- SO4 · Sulfate ion · in 38 records
- NAD · Nicotinamide-adenine-dinucleotide · in 28 records
- MG · Magnesium ion · in 17 records
- FDA · Dihydroflavine-adenine dinucleotide · in 7 records
- TFB · Tetrahydrofuran-2-carboxylic acid · in 6 records
- NAI · 1,4-dihydronicotinamide adenine dinucleotide · in 4 records
- T2C · (2S)-1,3-thiazolidine-2-carboxylic acid · in 4 records
- CBG · Propanal · in 3 records
- A1BDD · (4-methoxyphenyl)methanol · in 2 records
- UJD · 1,3-dithiolane-2-carboxylic acid · in 2 records
- UJG · [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-{7, 8-dimethyl-2,4-dioxo-5-[(2R)-tetrahydrothiophen-2-yl]-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl}-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name) · in 2 records
- UJJ · [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[5-(1,3-dithiolan-2-yl)-7,8-dimethyl-2,4-dioxo-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate · in 2 records
- UJM · (2S)-thiolane-2-carboxylic acid · in 2 records
- UJP · (2R)-thiolane-2-carboxylic acid · in 2 records
- 53E · 2,3-dihydro-1,4-benzodioxine-5-carboxylic acid · in 1 record
- 8P4 · 1-(4-fluorophenyl)thiourea · in 1 record
- A1AQC · (2,3-dihydro-1-benzofuran-5-yl)methanol · in 1 record
- A1AV8 · N-(prop-2-en-1-yl)glycine · in 1 record
- A1BDA · 5-chloro-2,3-dihydro-1H-inden-1-one · in 1 record
- A1BDB · (3S)-piperidine-3-carboxylic acid · in 1 record
- A1BDU · (1H-indol-5-yl)methanol · in 1 record
- A1BDV · (2H-1,3-benzodioxol-5-yl)methanol · in 1 record
- A1BDW · (1,4-phenylene)dimethanol · in 1 record
- A1BDX · (1-benzofuran-5-yl)methanol · in 1 record
- DPR · D-proline · in 1 record
- GHO · (1R)-1-hydroxyethane-1-sulfonic acid · in 1 record
- HYP · 4-hydroxyproline · in 1 record
- ID7 · (3R)-piperidine-3-carboxylic acid · in 1 record
- PRO · Proline · in 1 record
Elsewhere
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