UniProt A0A097J809
Endolysin,Autophagy-related protein 2 (A0A097J809)
Endolysin,Autophagy-related protein 2 (UniProt A0A097J809), EC 3.2.1.17: 34 experimental structures on GenesisL1, 15 ligands bound, 184 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A0A097J809
- Protein
- Endolysin,Autophagy-related protein 2
- EC
- 3.2.1.17
- Experimental structures
- 34
- Predicted models
- 0
- Ligands
- 15
- Pockets
- 184 · 30 records with a druggable one
Structures
34 records of A0A097J809 in the MolNFT archive: 34 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4UIS | The cryoEM structure of human gamma-Secretase complex | electron microscopy | G | — | 1 (best 0.52) |
| 4UIS | The cryoem structure of human gamma-secretase complex | electron microscopy | G | — | 1 (best 0.52) |
| 6A73 | Complex structure of CSN2 with IP6 | x-ray diffraction | A, B | IHP, SO4 | 4 (best 0.54) |
| 6A73 | Complex structure of CSN2 with IP6 | x-ray diffraction | A, B | IHP, SO4 | 4 (best 0.54) |
| 6A9E | Crystal structure of the N-terminal domain of Atg2 | x-ray diffraction | A, B | — | 10 (best 0.83) |
| 6A9E | Crystal structure of the N-terminal domain of ATG2 | x-ray diffraction | A, B | — | 10 (best 0.83) |
| 6A9J | Crystal structure of the PE-bound N-terminal domain of Atg2 | x-ray diffraction | A, B | PEE | 11 (best 0.85) |
| 6A9J | Crystal structure of the pe-bound N-terminal domain of ATG2 | x-ray diffraction | A, B | PEE | 11 (best 0.85) |
| 6E67 | Structure of beta2 adrenergic receptor fused to a Gs peptide | x-ray diffraction | A, B | P0G | 10 (best 0.77) |
| 6E67 | Structure of BETA2 adrenergic receptor fused to a gs peptide | x-ray diffraction | A, B | P0G | 10 (best 0.77) |
| 6IGK | Crystal Structure of human ETB receptor in complex with Endothelin-3 | x-ray diffraction | A | — | 5 (best 0.68) |
| 6IGK | Crystal structure of human etb receptor in complex with endothelin-3 | x-ray diffraction | A | — | 5 (best 0.68) |
| 6IGL | Crystal Structure of human ETB receptor in complex with IRL1620 | x-ray diffraction | A | SO4 | 7 (best 0.67) |
| 6IGL | Crystal structure of human etb receptor in complex with IRL1620 | x-ray diffraction | A | SO4 | 7 (best 0.67) |
| 6K41 | cryo-EM structure of alpha2BAR-GoA complex | electron microscopy | R | CZX | 3 (best 0.81) |
| 6K41 | Cryo-EM structure of ALPHA2BAR-goa complex | electron microscopy | R | CZX | 3 (best 0.81) |
| 6K42 | cryo-EM structure of alpha2BAR-Gi1 complex | electron microscopy | R | CZX | 7 (best 0.80) |
| 6K42 | Cryo-EM structure of ALPHA2BAR-GI1 complex | electron microscopy | R | CZX | 7 (best 0.80) |
| 6KPC | Crystal structure of an agonist bound GPCR | x-ray diffraction | A | E3R | 5 (best 0.85) |
| 6KPC | Crystal structure of an agonist bound GPCR | x-ray diffraction | A | E3R | 5 (best 0.85) |
| 6LRY | Crystal structure of human endothelin ETB receptor in complex with sarafotoxin S6b | x-ray diffraction | A | — | 6 (best 0.60) |
| 6LRY | Crystal structure of human endothelin etb receptor in complex with sarafotoxin S6B | x-ray diffraction | A | — | 6 (best 0.60) |
| 6N48 | Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric… | x-ray diffraction | A | P0G, 1WV, KBY | 6 (best 0.81) |
| 6N48 | Structure of BETA2 adrenergic receptor bound to BI167107, nanobody 6B9, and a positive allosteric… | x-ray diffraction | A | P0G, 1WV, KBY | 6 (best 0.81) |
| 6NI3 | B2V2R-Gs protein subcomplex of a GPCR-G protein-beta-arrestin mega-complex | electron microscopy | R | P0G | 5 (best 0.80) |
| 6NI3 | B2V2R-gs protein subcomplex of a GPCR-G protein-beta-arrestin mega- complex | electron microscopy | R | P0G | 5 (best 0.80) |
| 7C2M | Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with… | x-ray diffraction | A | FFU, L6T, MHA | 9 (best 0.82) |
| 7C2M | Crystal structure of mycolic acid transporter MMPL3 from mycobacterium smegmatis complexed with… | x-ray diffraction | A | FFU, L6T, MHA | — |
| 7C2N | Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with… | x-ray diffraction | A | L6T, MHA, FG0 | 7 (best 0.81) |
| 7C2N | Crystal structure of mycolic acid transporter MMPL3 from mycobacterium smegmatis complexed with… | x-ray diffraction | A | L6T, MHA, FG0 | — |
| 7DDZ | The Crystal Structure of Human Neuropeptide Y Y2 Receptor with JNJ-31020028 | x-ray diffraction | A | H46, FMN | 4 (best 0.78) |
| 7DDZ | The crystal structure of human neuropeptide Y Y2 receptor with jnj- 31020028 | x-ray diffraction | A | H46, FMN | — |
| 7KWA | Structure of DCN1 bound to N-((4S,5S)-3-(aminomethyl)-7-ethyl-4-(4-fluorophenyl)-6-oxo-1-phenyl-4,5… | x-ray diffraction | A | YHP | 4 (best 0.61) |
| 7KWA | Structure of DCN1 bound to N-((4S,5S)-3-(aminomethyl)-7-ethyl-4-(4… | x-ray diffraction | A | YHP | — |
Ligands
- P0G · 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl) ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one · in 6 records
- CZX · 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole · in 4 records
- L6T · alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside · in 4 records
- MHA · (carbamoylmethyl-carboxymethyl-amino)-acetic acid · in 4 records
- SO4 · Sulfate ion · in 4 records
- 1WV · (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate · in 2 records
- E3R · 7-[(6aR,9R,10aR)-1-Hydroxy-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-3-yl]- 7-methyloctanenitrile · in 2 records
- FFU · N-(4,4-dimethylcyclohexyl)-4,6-bis(fluoranyl)-1H-indole-2-carboxamide · in 2 records
- FG0 · 1'-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)spiro[6,7-dihydrothieno[3,2-c]pyran-4,4'-piperidine] · in 2 records
- FMN · Flavin mononucleotide · in 2 records
- H46 · ~{N}-[4-[4-[(1~{S})-2-(diethylamino)-2-oxidanylidene-1-phenyl-ethyl]piperazin-1-yl]-3-fluoranyl-phenyl]-2-pyridin-3-yl-benzamide · in 2 records
- IHP · Inositol hexakisphosphate · in 2 records
- KBY · N-[(3R)-4-(4-tert-butylphenyl)-3-({2-[(4-methoxyphenyl)sulfanyl]-5-[methyl(propan-2-yl) sulfamoyl]benzene-1-carbonyl}amino)butanoyl]glycine · in 2 records
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 2 records
- YHP · N-[(4S,5S)-3-(aminomethyl)-7-ethyl-4-(4-fluorophenyl)-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-3-(trifluoromethyl)benzamide · in 2 records
Experiment against prediction
- 7DDZ chain A against the predicted model P00323: TM-score 0.34, RMSD 0.43 Å
- 7DDZ chain A against the predicted model P00323: TM-score 0.34, RMSD 0.43 Å
- 6K41 chain R against the predicted model P18089: TM-score 0.93, RMSD 2.13 Å
- 6K41 chain R against the predicted model P18089: TM-score 0.93, RMSD 2.13 Å
- 6NI3 chain R against the predicted model P07550: TM-score 0.93, RMSD 1.89 Å
- 6NI3 chain R against the predicted model P07550: TM-score 0.93, RMSD 1.89 Å
- 6K41 chain R against the predicted model Q28838: TM-score 0.91, RMSD 2.34 Å
- 6K41 chain R against the predicted model Q28838: TM-score 0.91, RMSD 2.34 Å
- 6K42 chain R against the predicted model P18089: TM-score 0.91, RMSD 2.40 Å
- 6K42 chain R against the predicted model P18089: TM-score 0.91, RMSD 2.40 Å
Elsewhere
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