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Ligand · CZX

CZX · 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole

CZX, 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole (C13 H16 N2, 200.3 g/mol), in the MolNFT structures on GenesisL1: bound in 5 records (4 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds…

Component
CZX
Formula
C13 H16 N2
Class
ligand
Structures
5
PDB entries
4

Binding sites

CZX in 5 structures; the first of them:

  • 6K42 · cryo-EM structure of alpha2BAR-Gi1 complex · CZX R501 · binds ASP92, VAL93, CYS96, THR97, LEU166, SER176, SER177, SER180 and 7 more
  • 9CBM · Cryo-EM structure of dexmedetomidine-bound alpha-2A-adrenergic receptor in complex with… · CZX R501 · binds ASP128, VAL129, CYS132, THR133, SER215, SER219, TRP402, PHE405 and 5 more
  • 6K41 · Cryo-EM structure of ALPHA2BAR-goa complex · CZX R501 · binds ASP92, VAL93, CYS96, THR97, LEU166, SER176, SER180, TRP384 and 5 more
  • 6K42 · Cryo-EM structure of ALPHA2BAR-GI1 complex · CZX R501 · binds ASP92, VAL93, CYS96, THR97, LEU166, SER176, SER180, TRP384 and 5 more
  • 7EJA · Structure of the ALPHA2A-adrenergic receptor goa signaling complex bound to… · CZX R501 · binds ASP128, VAL129, CYS132, SER215, TRP402, PHE405, PHE427, TYR431

Residues it binds most

PHE 5, SER 5, TYR 5, ASP 5, CYS 5, TRP 5, VAL 5, THR 4, GLY 3, LEU 3 (residue and the binding sites it lines).

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