MolNFT v1 · #156063 · protein
Crystal structure of human endothelin etb receptor in complex with sarafotoxin S6B
6LRY · Endothelin receptor type B,ENDOLYSIN,ENDOTHELIN receptor…: “Crystal structure of human endothelin etb receptor in complex with sarafotoxin S6B”. X-ray diffraction, 6 pockets (best druggability 0.60). MolNFT v1 #156063 on GenesisL1…
- PDB
- 6LRY
- Type
- protein
- Length
- 489 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Endothelin receptor type B,ENDOLYSIN,ENDOTHELIN receptor type B; Sarafotoxin-B
- EC
- 3.2.1.17
- UniProt
- P24530, A0A097J809, P13208
- Pockets
- 6 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Endothelin receptor type B,ENDOLYSIN,ENDOTHELIN receptor type B (EC 3.2.1.17) | protein | 468 | 70% helix, 7% strand | P24530, A0A097J809 |
| B | Sarafotoxin-B | protein | 21 | 43% helix, 0% strand | P13208 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 224 | 0.60 | 0.81 | 35 | empty |
| 2 | 112 | 0.57 | 0.84 | 23 | empty |
| 3 | 140 | 0.50 | 0.79 | 23 | empty |
| 4 | 139 | 0.39 | 0.74 | 24 | empty |
| 5 | 67 | 0.32 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1652 Ų buried · 28 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6LRY · Crystal structure of human endothelin ETB receptor in complex with sarafotoxin S6b · the same entry in another collection · chain A against A, TM-score 1.00
- P24530 · AlphaFold monomer V2.0 prediction for endothelin receptor type B (P24530) · a predicted model of the same protein · chain A against A, TM-score 0.65
- P13208 · AlphaFold monomer V2.0 prediction for sarafotoxin (P13208) · a predicted model of the same protein · chain B against A, TM-score 0.42
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24530
- Every structure of UniProt A0A097J809
- Every structure of UniProt P13208
- Elsewhere: RCSB PDB 6LRY · PDBe 6LRY · UniProt P24530 · UniProt A0A097J809 · UniProt P13208
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