UniProt P24530
Endothelin receptor type B (P24530)
Endothelin receptor type B (UniProt P24530), EC 1.13.12.13, 3.2.1.17: 15 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 49 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P24530
- Protein
- Endothelin receptor type B
- EC
- 1.13.12.13, 3.2.1.17, 3.2.1.18
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 49 · 9 records with a druggable one
Structures
16 records of P24530 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5X93 | Human endothelin receptor type-B in complex with antagonist K-8794 | x-ray diffraction | A | K87, CLR, SO4 | — |
| 5XPR | Human endothelin receptor type-B in complex with antagonist bosentan | x-ray diffraction | A | K86, SO4 | 5 (best 0.72) |
| 5XPR | Human endothelin receptor type-B in complex with antagonist bosentan | x-ray diffraction | A | K86, SO4 | — |
| 6IGK | Crystal structure of human etb receptor in complex with endothelin-3 | x-ray diffraction | A | — | — |
| 6IGL | Crystal structure of human etb receptor in complex with IRL1620 | x-ray diffraction | A | SO4 | — |
| 6K1Q | Human endothelin receptor type-B in complex with inverse agonist IRL2500 | x-ray diffraction | A | D2U, PO4 | 8 (best 0.75) |
| 6K1Q | Human endothelin receptor type-B in complex with inverse agonist IRL2500 | x-ray diffraction | A | D2U, PO4 | — |
| 6LRY | Crystal structure of human endothelin ETB receptor in complex with sarafotoxin S6b | x-ray diffraction | A | — | 6 (best 0.60) |
| 6LRY | Crystal structure of human endothelin etb receptor in complex with sarafotoxin S6B | x-ray diffraction | A | — | — |
| 8HBD | Cryo-EM structure of IRL1620-bound ETBR-Gi complex | electron microscopy | R | — | 5 (best 0.74) |
| 8XVE | Cryo-EM structure of ETBR bound with BQ3020 | electron microscopy | R | — | 5 (best 0.77) |
| 8XVH | Cryo-EM structure of ETBR bound with Endothelin1 | electron microscopy | R | — | 5 (best 0.76) |
| 8XWP | Cryo-EM structure of ET-1 bound ETBR-DNGI complex | electron microscopy | R | — | 6 (best 0.78) |
| 8XWQ | Cryo-EM structure of ET-1 bound ETBR-DNGI complex | electron microscopy | R | — | 6 (best 0.79) |
| 8ZRT | Cryo-EM structure focused on the receptor of the ET-1 bound ETBR-DNGI complex | electron microscopy | R | — | 3 (best 0.71) |
| P24530 | AlphaFold monomer V2.0 prediction for endothelin receptor type B (P24530) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 4 records
- D2U · (2~{S})-2-[[(2~{R})-2-[(3,5-dimethylphenyl)carbonyl-methyl-amino]-3-(4-phenylphenyl)propanoyl]amino]-3-(1~{H}-indol-3-yl)propanoic acid · in 2 records
- K86 · 4-tert-butyl-N-[6-(2-hydroxyethyloxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]benzenesulfonamide · in 2 records
- PO4 · Phosphate ion · in 2 records
- CLR · Cholesterol · in 1 record
- K87 · 3-[6-[(4-tert-butylphenyl)sulfonylamino]-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]oxy-N-(2,6-dimethylphenyl)propanamide · in 1 record
Experiment against prediction
- 8ZRT chain R against the predicted model P24530: TM-score 0.96, RMSD 1.39 Å
- 8XVE chain R against the predicted model P24530: TM-score 0.95, RMSD 1.80 Å
- 8XWQ chain R against the predicted model P24530: TM-score 0.95, RMSD 1.78 Å
- 8XWP chain R against the predicted model P24530: TM-score 0.94, RMSD 1.76 Å
- 8HBD chain R against the predicted model P24530: TM-score 0.94, RMSD 1.94 Å
- 8XVH chain R against the predicted model P24530: TM-score 0.93, RMSD 2.04 Å
- 6IGK chain A against the predicted model P24530: TM-score 0.66, RMSD 1.11 Å
- 5XPR chain A against the predicted model P24530: TM-score 0.70, RMSD 2.49 Å
- 5XPR chain A against the predicted model P24530: TM-score 0.70, RMSD 2.49 Å
- 5X93 chain A against the predicted model P24530: TM-score 0.69, RMSD 2.31 Å
Elsewhere
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