Research workbench
Crystal structure of human endothelin etb receptor in complex with sarafotoxin S6B
Analyse Crystal structure of human endothelin etb receptor in complex with sarafotoxin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6LRY
- Type
- protein
- Length
- 489 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Endothelin receptor type B,ENDOLYSIN,ENDOTHELIN receptor type B; Sarafotoxin-B
- EC
- 3.2.1.17
- UniProt
- P24530, A0A097J809, P13208
- Pockets
- 6 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Endothelin receptor type B,ENDOLYSIN,ENDOTHELIN receptor type B (EC 3.2.1.17) | protein | 468 | 70% helix, 7% strand | P24530, A0A097J809 |
| B | Sarafotoxin-B | protein | 21 | 43% helix, 0% strand | P13208 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 224 | 0.60 | 0.81 | 35 | empty |
| 2 | 112 | 0.57 | 0.84 | 23 | empty |
| 3 | 140 | 0.50 | 0.79 | 23 | empty |
| 4 | 139 | 0.39 | 0.74 | 24 | empty |
| 5 | 67 | 0.32 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1652 Ų buried · 28 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6LRY · Crystal structure of human endothelin ETB receptor in complex with sarafotoxin S6b · the same entry in another collection · chain A against A, TM-score 1.00
- P24530 · AlphaFold monomer V2.0 prediction for endothelin receptor type B (P24530) · a predicted model of the same protein · chain A against A, TM-score 0.65
- P13208 · AlphaFold monomer V2.0 prediction for sarafotoxin (P13208) · a predicted model of the same protein · chain B against A, TM-score 0.42
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24530
- Every structure of UniProt A0A097J809
- Every structure of UniProt P13208
- Elsewhere: RCSB PDB 6LRY · PDBe 6LRY · UniProt P24530 · UniProt A0A097J809 · UniProt P13208
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