MolNFT v2 · #210321 · protein
Cryo-EM structure of an orphan GPCR-Gi protein signaling complex
8G05: “Cryo-EM structure of an orphan GPCR-Gi protein signaling complex”. Electron microscopy at 3.0, 2 ligands (YI9, CLR). MolNFT v2 #210321 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 8G05
- Type
- protein
- Length
- 1,140 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.0
- Source
- Homo sapiens
- UniProt
- Q9NQS5, P63096, P62873, P59768
- Ligands
- YI9, CLR
Structure
electron microscopy · resolution 3.0 · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| R | — | protein | 286 | — | Q9NQS5 |
| A | — | protein | 224 | — | P63096 |
| B | — | protein | 342 | — | P62873 |
| E | — | protein | 231 | — | — |
| G | — | protein | 57 | — | P59768 |
Ligands and binding sites
- YI9 · 6-(octylamino)pyrimidine-2,4(3H,5H)-dione · ligand · chains R
- CLR · Cholesterol · ligand · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.97
- Q9NQS5 · AlphaFold monomer V2.0 prediction for G-protein coupled receptor 84 (Q9NQS5) · a predicted model of the same protein · chain R against A, TM-score 0.91
- P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NQS5
- Every structure of UniProt P63096
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 8G05 · PDBe 8G05 · UniProt Q9NQS5 · UniProt P63096 · UniProt P62873 · UniProt P59768
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.