GL1X · GenesisL1 explorer

MolNFT v2 · #197963 · protein

Cryo-EM structure of the CCL15(27-92) bound CCR1-Gi complex

7VLA: “Cryo-EM structure of the CCL15(27-92) bound CCR1-Gi complex”. Electron microscopy at 2.7, 1 ligand (CLR). MolNFT v2 #197963 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
7VLA
Type
protein
Length
1,222 residues
Chains
6
Method
electron microscopy
Collection
MolNFT v2 / PDB Bank
Contract
0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner
0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution
2.7
Source
Homo sapiens
UniProt
P63096, P62873, P59768, Q16663, P32246
Ligands
CLR

Structure

electron microscopy · resolution 2.7 · 6 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein225—P63096
B—protein339—P62873
G—protein58—P59768
L—protein64—Q16663
R—protein302—P32246
S—protein234——

Ligands and binding sites

  • CLR · Cholesterol · ligand · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 7VLA · Cryo-EM structure of the CCL15(27-92) bound CCR1-gi complex · the same entry in another collection · chain S against S, TM-score 1.00
  • P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
  • P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.95
  • P32246 · AlphaFold monomer V2.0 prediction for C-C chemokine receptor type 1 (P32246) · a predicted model of the same protein · chain R against A, TM-score 0.93
  • Q16663 · AlphaFold monomer V2.0 prediction for C-C motif chemokine 15 (Q16663) · a predicted model of the same protein · chain L against A, TM-score 0.88
  • P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.82

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