MolNFT v2 · #185567 · protein
PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R):Gs complex
7LCI: “PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R):Gs complex”. Electron microscopy at 2.9, 1 ligand (UK4). MolNFT v2 #185567 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7LCI
- Type
- protein
- Length
- 1,032 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.9
- Source
- Homo sapiens
- UniProt
- P43220, P63092, P62873, P59768
- Ligands
- UK4
Structure
electron microscopy · resolution 2.9 · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| R | — | protein | 393 | — | P43220 |
| A | — | protein | 244 | — | P63092 |
| B | — | protein | 338 | — | P62873 |
| G | — | protein | 57 | — | P59768 |
Ligands and binding sites
- UK4 · 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid · ligand · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7LCI · Pf 06882961 bound to the glucagon-like peptide-1 receptor (glp-1R):GS complex · the same entry in another collection · chain R against R, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.92
- P63092 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(S) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.87
- P43220 · AlphaFold monomer V2.0 prediction for glucagon-like peptide 1 receptor (P43220) · a predicted model of the same protein · chain R against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43220
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 7LCI · PDBe 7LCI · UniProt P43220 · UniProt P63092 · UniProt P62873 · UniProt P59768
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