GL1X · GenesisL1 explorer

MolNFT v2 · #175543 · protein

Structure of a minimal SF3B core in complex with spliceostatin A (form II)

7B0I: “Structure of a minimal SF3B core in complex with spliceostatin A (form II)”. X-ray diffraction at 3, 2 ligands (SJT, ZN). MolNFT v2 #175543 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
7B0I
Type
protein
Length
1,864 residues
Chains
4
Method
x-ray diffraction
Collection
MolNFT v2 / PDB Bank
Contract
0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner
0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution
3
Source
Homo sapiens
UniProt
Q15393, Q9BWJ5, O75533, Q7RTV0
Ligands
SJT, ZN

Structure

x-ray diffraction · resolution 3 · 4 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein864—Q15393
B—protein65—Q9BWJ5
C—protein842—O75533
D—protein93—Q7RTV0

Ligands and binding sites

  • SJT · spliceostatin A (form II) · ligand · chains C, D
  • ZN · Zinc ion · metal · 3 copies · chains D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 7B0I · Structure of a minimal SF3B core in complex with spliceostatin a (form II) · the same entry in another collection · chain D against D, TM-score 1.00
  • Q15393 · AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 3 (Q15393) · a predicted model of the same protein · chain A against A, TM-score 0.99
  • Q9BWJ5 · AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 5 (Q9BWJ5) · a predicted model of the same protein · chain B against A, TM-score 0.92
  • Q7RTV0 · AlphaFold monomer V2.0 prediction for phd finger-like domain- containing protein 5A… · a predicted model of the same protein · chain D against A, TM-score 0.88
  • O75533 · AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 1 (O75533) · a predicted model of the same protein · chain C against A, TM-score 0.80

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