MolNFT v1 · #68294 · protein
NUP84-NUP145C-SEC13 edge element of the npc lattice
3JRO · Fusion protein of protein transport protein SEC13 and…: “NUP84-NUP145C-SEC13 edge element of the npc lattice”. X-ray diffraction, 19 pockets (best druggability 0.84). MolNFT v1 #68294 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3JRO
- Type
- protein
- Length
- 1,080 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion protein of protein transport protein SEC13 and nucleoporin NUP145; Nucleoporin…
- UniProt
- Q04491, P49687, P52891
- Pockets
- 19 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fusion protein of protein transport protein SEC13 and nucleoporin NUP145 | protein | 701 | 32% helix, 21% strand | Q04491, P49687 |
| C | Nucleoporin NUP84 | protein | 379 | 59% helix, 0% strand | P52891 |
Pockets
19 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 899 | 0.84 | 0.86 | 70 | empty |
| 2 | 495 | 0.77 | 0.85 | 63 | empty |
| 3 | 518 | 0.69 | 0.79 | 52 | empty |
| 4 | 151 | 0.68 | 0.88 | 34 | empty |
| 5 | 279 | 0.67 | 0.82 | 45 | empty |
Interfaces
1 interface between chains.
- A–C · 2118 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 3JRO · NUP84-NUP145C-SEC13 edge element of the NPC lattice · the same entry in another collection · chain A against A, TM-score 1.00
- P52891 · AlphaFold monomer V2.0 prediction for nucleoporin NUP84 (P52891) · a predicted model of the same protein · chain C against A, TM-score 0.95
- P49687 · AlphaFold monomer V2.0 prediction for nucleoporin NUP145 (P49687) · a predicted model of the same protein · chain A against A, TM-score 0.61
- Q04491 · AlphaFold monomer V2.0 prediction for protein transport protein SEC13 (Q04491) · a predicted model of the same protein · chain A against A, TM-score 0.39
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q04491
- Every structure of UniProt P49687
- Every structure of UniProt P52891
- Elsewhere: RCSB PDB 3JRO · PDBe 3JRO · UniProt Q04491 · UniProt P49687 · UniProt P52891
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