Cryo-EM structure of the 5HT2C receptor (vsv isoform) bound to lorcaserin

Structure

electron microscopy · 5 distinct chains.

Ligands and binding sites

• T4U · (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine · ligand · chains A
• CLR · Cholesterol · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 8DPI · Cryo-EM structure of the 5HT2C receptor (VSV isoform) bound to lorcaserin · the same entry in another collection · chain E against E, TM-score 1.00
• P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain C against A, TM-score 0.99
• P28335 · AlphaFold monomer V2.0 prediction for 5-hydroxytryptamine receptor 2C (P28335) · a predicted model of the same protein · chain A against A, TM-score 0.93
• P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain D against A, TM-score 0.87

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P28335
• Every structure of UniProt P62873
• Every structure of UniProt P59768
• Elsewhere: RCSB PDB 8DPI · PDBe 8DPI · UniProt P28335 · UniProt P62873 · UniProt P59768