UniProt P28335
5-hydroxytryptamine receptor 2C,Soluble cytochrome b562 (P28335)
5-hydroxytryptamine receptor 2C,Soluble cytochrome b562 (UniProt P28335): 9 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 14 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P28335
- Protein
- 5-hydroxytryptamine receptor 2C,Soluble cytochrome b562
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 14 · 3 records with a druggable one
Structures
10 records of P28335 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6BQG | Crystal structure of 5-HT2C in complex with ergotamine | x-ray diffraction | A | ERM | 4 (best 0.77) |
| 6BQG | Crystal structure of 5-HT2C in complex with ergotamine | x-ray diffraction | A | ERM | — |
| 6BQH | Crystal structure of 5-HT2C in complex with ritanserin | x-ray diffraction | A | E2J, OLA | 6 (best 0.80) |
| 6BQH | Crystal structure of 5-HT2C in complex with ritanserin | x-ray diffraction | A | E2J, OLA | — |
| 8DPF | Cryo-EM structure of the 5HT2C receptor (ini isoform) bound to lorcaserin | electron microscopy | A | T4U, CLR | — |
| 8DPG | Cryo-EM structure of the 5HT2C receptor (ini isoform) bound to psilocin | electron microscopy | A | 91Q, CLR | — |
| 8DPH | Cryo-EM structure of the 5HT2C receptor (vgv isoform) bound to lorcaserin | electron microscopy | A | T4U, CLR | — |
| 8DPI | Cryo-EM structure of the 5HT2C receptor (vsv isoform) bound to lorcaserin | electron microscopy | A | T4U, CLR | — |
| 8ZMF | Crystal structure of an inverse agonist antipsychotic drug derivative-bound 5-HT2C | x-ray diffraction | A | A1L10 | 4 (best 0.80) |
| P28335 | AlphaFold monomer V2.0 prediction for 5-hydroxytryptamine receptor 2C (P28335) | predicted | A | — | — |
Ligands
- CLR · Cholesterol · in 4 records
- T4U · (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine · in 3 records
- E2J · 6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one · in 2 records
- ERM · Ergotamine · in 2 records
- OLA · Oleic acid · in 2 records
- 91Q · 3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol · in 1 record
- A1L10 · 1-[(4-fluorophenyl)methyl]-1-[(8~{S})-5-methyl-5-azaspiro[2.5]octan-8-yl]-3-[[4-(2-methylpropoxy)phenyl]methyl]urea · in 1 record
Experiment against prediction
- 8DPG chain A against the predicted model P28335: TM-score 0.93, RMSD 1.87 Å
- 8DPH chain A against the predicted model P28335: TM-score 0.93, RMSD 1.89 Å
- 8DPI chain A against the predicted model P28335: TM-score 0.93, RMSD 1.91 Å
- 8DPF chain A against the predicted model P28335: TM-score 0.93, RMSD 1.91 Å
- 8ZMF chain A against the predicted model P28335: TM-score 0.89, RMSD 2.28 Å
- 6BQH chain A against the predicted model P28335: TM-score 0.84, RMSD 2.60 Å
- 6BQH chain A against the predicted model P28335: TM-score 0.84, RMSD 2.60 Å
- 6BQG chain A against the predicted model P28335: TM-score 0.76, RMSD 2.88 Å
- 6BQG chain A against the predicted model P28335: TM-score 0.76, RMSD 2.88 Å
- 6BQG chain A against the predicted model P0ABE7: TM-score 0.26, RMSD 1.87 Å
Elsewhere
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