Crystal structure of 5-HT2C in complex with ritanserin

Structure

x-ray diffraction · 1 distinct chain.

Ligands and binding sites

• OLA · Oleic acid · ligand · 2 copies · chains A
• E2J · 6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one · ligand · chains A
• OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · 6 copies · chains A
• PEG · Di(hydroxyethyl)ether · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6BQH · Crystal structure of 5-HT2C in complex with ritanserin · the same entry in another collection · chain A against A, TM-score 1.00
• P28335 · AlphaFold monomer V2.0 prediction for 5-hydroxytryptamine receptor 2C (P28335) · a predicted model of the same protein · chain A against A, TM-score 0.84
• P0ABE7 · AlphaFold monomer V2.0 prediction for soluble cytochrome B562 (P0ABE7) · a predicted model of the same protein · chain A against A, TM-score 0.22

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P28335
• Every structure of UniProt P0ABE7
• Elsewhere: RCSB PDB 6BQH · PDBe 6BQH · UniProt P28335 · UniProt P0ABE7