MolNFT v1 · #191428 · protein
Cryo-EM structure of the 5HT2C receptor (ini isoform) bound to psilocin
8DPG: “Cryo-EM structure of the 5HT2C receptor (ini isoform) bound to psilocin”. Electron microscopy, 2 ligands (91Q, CLR). MolNFT v1 #191428 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 8DPG
- Type
- protein
- Length
- 1,093 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P28335, P62873, P59768
- Ligands
- 91Q, CLR
Structure
electron microscopy · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 264 | — | P28335 |
| B | — | protein | 221 | — | — |
| C | — | protein | 336 | — | P62873 |
| D | — | protein | 42 | — | P59768 |
| E | — | protein | 230 | — | — |
Ligands and binding sites
- 91Q · 3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol · ligand · chains A
- CLR · Cholesterol · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 8DPG · Cryo-EM structure of the 5HT2C receptor (INI isoform) bound to psilocin · the same entry in another collection · chain E against E, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain C against A, TM-score 0.99
- P28335 · AlphaFold monomer V2.0 prediction for 5-hydroxytryptamine receptor 2C (P28335) · a predicted model of the same protein · chain A against A, TM-score 0.93
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain D against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28335
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 8DPG · PDBe 8DPG · UniProt P28335 · UniProt P62873 · UniProt P59768
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