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Ligand · T4U

T4U · (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

T4U, (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (C11 H14 Cl N, 195.7 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it…

Component
T4U
Formula
C11 H14 Cl N
Class
ligand
Structures
6
PDB entries
3

Binding sites

T4U in 6 structures; the first of them:

  • 8DPF · Cryo-EM structure of the 5HT2C receptor (INI isoform) bound to lorcaserin · T4U A501 · binds ASP134, VAL135, SER138, PHE214, GLY218, SER219, ALA222, PHE327 and 2 more
  • 8DPH · Cryo-EM structure of the 5HT2C receptor (VGV isoform) bound to lorcaserin · T4U A501 · binds ASP134, VAL135, SER138, SER219, PHE327, PHE328, VAL354, TYR358
  • 8DPI · Cryo-EM structure of the 5HT2C receptor (VSV isoform) bound to lorcaserin · T4U A501 · binds ASP134, VAL135, SER138, GLY218, SER219, ALA222, PHE327, PHE328 and 2 more
  • 8DPF · Cryo-EM structure of the 5HT2C receptor (ini isoform) bound to lorcaserin · T4U A501 · binds ASP134, VAL135, SER138, GLY218, SER219, PHE327, VAL354
  • 8DPH · Cryo-EM structure of the 5HT2C receptor (vgv isoform) bound to lorcaserin · T4U A501 · binds ASP134, VAL135, SER138, SER219, VAL354, TYR358
  • 8DPI · Cryo-EM structure of the 5HT2C receptor (vsv isoform) bound to lorcaserin · T4U A501 · binds ASP134, VAL135, SER138, GLY218, SER219, ALA222, PHE327

Residues it binds most

SER 6, VAL 6, PHE 5, ASP 6, GLY 4, ALA 3, TYR 3 (residue and the binding sites it lines).

Found with

  • CLR · Cholesterol

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