MolNFT v1 · #190612 · protein
Cryoem structure of the somatostatin receptor 2 (SSTR2) in complex with GI1 and its endogeneous peptide ligand sst-14
7XMR · Somatostatin receptor type 2: “Cryoem structure of the somatostatin receptor 2 (SSTR2) in complex with GI1 and its endogeneous peptide…”. Electron microscopy, 5 pockets (best druggability 0.82). MolNFT v1 #190612 on GenesisL1: 3D…
- PDB
- 7XMR
- Type
- protein
- Length
- 871 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Somatostatin receptor type 2; Guanine nucleotide-binding protein G(I) subunit alpha-1…
- UniProt
- P30874, P63096, P62873, P59768, P61278
- Pockets
- 5 · best druggability 0.82
Structure
electron microscopy · 5 distinct chains · 39% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| R | Somatostatin receptor type 2 | protein | 285 | 79% helix, 4% strand | P30874 |
| A | Guanine nucleotide-binding protein G(I) subunit alpha-1 | protein | 224 | 42% helix, 18% strand | P63096 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 314 | 0% helix, 46% strand | P62873 |
| C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 34 | 53% helix, 0% strand | P59768 |
| L | Somatostatin-14 | protein | 14 | 0% helix, 14% strand | P61278 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 709 | 0.82 | 0.86 | 71 | empty |
| 2 | 1186 | 0.73 | 0.77 | 91 | empty |
| 3 | 91 | 0.39 | 0.77 | 17 | empty |
| 4 | 55 | 0.30 | 0.75 | 10 | empty |
| 5 | 52 | 0.26 | 0.73 | 14 | empty |
Interfaces
5 interfaces between chains.
- B–C · 1375 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1234 Ų buried · 13 hydrogen bonds · protein-protein
- R–A · 1232 Ų buried · 13 hydrogen bonds · protein-protein
- R–L · 1154 Ų buried · 13 hydrogen bonds · protein-protein
- R–B · 27 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7XMR · CryoEM structure of the somatostatin receptor 2 (SSTR2) in complex with Gi1 and its… · the same entry in another collection · chain L against L, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P30874 · AlphaFold monomer V2.0 prediction for somatostatin receptor type 2 (P30874) · a predicted model of the same protein · chain R against A, TM-score 0.89
- P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.83
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain C against A, TM-score 0.74
- P61278 · AlphaFold monomer V2.0 prediction for somatostatin (P61278) · a predicted model of the same protein · chain L against A, TM-score 0.20
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30874
- Every structure of UniProt P63096
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P61278
- Elsewhere: RCSB PDB 7XMR · PDBe 7XMR · UniProt P30874 · UniProt P63096 · UniProt P62873 · UniProt P59768 · UniProt P61278
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