Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with CX3CL1 and GI1

Structure

electron microscopy · 4 distinct chains.

Ligands and binding sites

• CLR · Cholesterol · ligand · 2 copies · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7XBX · Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with CX3CL1 and Gi1 · the same entry in another collection · chain D against D, TM-score 1.00
• P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain D against A, TM-score 0.98
• P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain E against A, TM-score 0.86
• P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain C against A, TM-score 0.81
• P49238 · AlphaFold monomer V2.0 prediction for CX3C chemokine receptor 1 (P49238) · a predicted model of the same protein · chain R against A, TM-score 0.80
• P78423 · AlphaFold monomer V2.0 prediction for fractalkine (P78423) · a predicted model of the same protein · chain R against A, TM-score 0.20

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P63096
• Every structure of UniProt P62873
• Every structure of UniProt P59768
• Every structure of UniProt P78423
• Every structure of UniProt P49238
• Elsewhere: RCSB PDB 7XBX · PDBe 7XBX · UniProt P63096 · UniProt P62873 · UniProt P59768 · UniProt P78423 · UniProt P49238