MolNFT v1 · #189990 · protein
Cryo-EM structure of human NAV1.7(E406K)-BETA1-BETA2 complex
7W9L: “Cryo-EM structure of human NAV1.7(E406K)-BETA1-BETA2 complex”. Electron microscopy, 6 ligands (LPE, Y01, PCW). MolNFT v1 #189990 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7W9L
- Type
- protein
- Length
- 1,714 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q15858, Q07699, O60939
- Ligands
- LPE, Y01, PCW, 9Z9, P5S, NAG
Structure
electron microscopy · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 1422 | — | Q15858 |
| B | — | protein | 173 | — | Q07699 |
| C | — | protein | 119 | — | O60939 |
Ligands and binding sites
- LPE · 1-O-octadecyl-sn-glycero-3-phosphocholine · ligand · 14 copies · chains A, B
- Y01 · Cholesterol hemisuccinate · ligand · 6 copies · chains A
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · ligand · 5 copies · chains A
- 9Z9 · (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en · ligand · chains A
- P5S · O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy) propyl]oxy}(hydroxy)phosphoryl]-L-serine · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 11 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7W9L · Cryo-EM structure of human Nav1.7(E406K)-beta1-beta2 complex · the same entry in another collection · chain B against B, TM-score 1.00
- O60939 · AlphaFold monomer V2.0 prediction for sodium channel subunit beta-2 (O60939) · a predicted model of the same protein · chain C against A, TM-score 0.99
- Q07699 · AlphaFold monomer V2.0 prediction for sodium channel subunit beta-1 (Q07699) · a predicted model of the same protein · chain B against A, TM-score 0.93
- Q15858 · AlphaFold monomer V2.0 prediction for sodium channel protein type 9 subunit alpha (Q15858) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15858
- Every structure of UniProt Q07699
- Every structure of UniProt O60939
- Elsewhere: RCSB PDB 7W9L · PDBe 7W9L · UniProt Q15858 · UniProt Q07699 · UniProt O60939
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