LPE · 1-O-octadecyl-sn-glycero-3-phosphocholine

Binding sites

LPE in 22 structures; the first of them:

• 7DRT · Human Wntless in complex with Wnt3a · LPE B602 · binds TRP253, THR257, MET259, ARG261, PRO262, PRO263, PHE271, ALA272 and 3 more
• 7W9M · Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits… · LPE B304 · binds ILE1181, ILE179, TYR182
• 7W9T · Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits… · LPE A2010 · binds MET763, HIS765, PHE772
• 7XVE · Human Nav1.7 mutant class-I · LPE A2005 · binds LEU759, MET763, HIS765, PHE772
• 8I5G · Structure of human Nav1.7 in complex with PF-05089771 · LPE A2007 · binds PRO1733, SER1734, ILE1737, PHE1738, VAL1741, SER1742, ILE1745, ILE1746

Residues it binds most

PHE 111, LEU 97, ILE 85, TYR 86, MET 71, VAL 67, SER 59, ALA 65, TRP 42, LYS 58 (residue and the binding sites it lines).

Found with

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
• PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine
• Y01 · Cholesterol hemisuccinate
• CLR · Cholesterol
• P5S · O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy) propyl]oxy}(hydroxy)phosphoryl]-L-serine
• 1PW · (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
• 9Z9 · (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en
• 95T · 5-(4-chlorophenyl)-~{N}-(3,5-dimethoxyphenyl)furan-2-carboxamide
• 9SL · [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate
• 9SR · (1R,5R,6R,7R,9S,11S,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5, 9,12,13,14-pentol (non-preferred name)
• PAM · Palmitoleic acid
• NA · Sodium ion