1PW · (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate

Binding sites

1PW in 6 structures; the first of them:

• 7XVE · Human Nav1.7 mutant class-I · 1PW A2007 · binds ILE1318, ILE1321, MET1322, LEU1325, LEU1400, THR1404, LEU1449, PHE1452 and 6 more
• 8XMM · Voltage-gated sodium channel Nav1.7 variant M9 · 1PW A2005 · binds ILE1318, ILE1321, MET1322, LEU1325, LEU1400, THR1404, LEU1449, PHE1452 and 5 more
• 7W9K · Cryo-EM structure of human NAV1.7-BETA1-BETA2 complex at 2.2 ångström resolution · 1PW A2013 · binds ILE1321, MET1322, LEU1325, THR1404, THR1695, THR1696, SER1697, ILE1744 and 5 more
• 7W9P · Cryo-EM structure of human NAV1.7(E406K) in complex with auxiliary beta subunits… · 1PW A2011 · binds GLN360, PHE391, ILE1321, LEU1325, THR1404, PHE1452, THR1696, SER1697 and 6 more
• 7XVE · Human NAV1.7 mutant class-I · 1PW A2007 · binds ILE1318, ILE1321, MET1322, THR1404, LEU1449, PHE1452, SER1697, ILE1744 and 2 more
• 7XVF · NAV1.7 mutant CLASS2 · 1PW A2007 · binds ILE1318, ILE1321, MET1322, LEU1325, THR1404, LEU1449, PHE1452, SER1697 and 4 more

Residues it binds most

ILE 6, LEU 6, PHE 6, THR 6, SER 6, MET 5, VAL 3, GLN 1 (residue and the binding sites it lines).

Found with

• LPE · 1-O-octadecyl-sn-glycero-3-phosphocholine
• PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
• Y01 · Cholesterol hemisuccinate
• CLR · Cholesterol
• P5S · O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy) propyl]oxy}(hydroxy)phosphoryl]-L-serine
• 9SL · [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate
• 9Z9 · (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en
• NA · Sodium ion