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UniProt Q15858

Sodium channel protein type 9 subunit alpha (Q15858)

Sodium channel protein type 9 subunit alpha (UniProt Q15858): 28 experimental structures and 1 predicted model on GenesisL1, 19 ligands bound, 160 pockets. Binding sites, druggability and experiment against prediction (TM-score)…

UniProt
Q15858
Protein
Sodium channel protein type 9 subunit alpha
Experimental structures
28
Predicted models
1
Ligands
19
Pockets
160 · 8 records with a druggable one

Structures

29 records of Q15858 in the MolNFT archive: 28 experimental, 1 predicted.

EntryTitleMethodChainsLigandsPockets
5EK0Human NAV1.7-VSD4-navab in complex with gx-936.x-ray diffractionA, B, C, D——
6J8GStructure of human voltage-gated sodium channel NAV1.7 in complex with auxiliary beta subunits…electron microscopyANAG, 9SL—
6J8HStructure of human voltage-gated sodium channel NAV1.7 in complex with auxiliary beta subunits…electron microscopyANAG, 9SL—
6J8IStructure of human voltage-gated sodium channel NAV1.7 in complex with auxiliary beta subunits…electron microscopyANAG, 9SR—
6J8JStructure of human voltage-gated sodium channel NAV1.7 in complex with auxiliary beta subunits…electron microscopyANAG, 9SR—
6N4QCryoem structure of NAV1.7 VSD2 (actived state) in complex with the gating modifier toxin PROTX2electron microscopyA, B, C, D——
6N4RCryoem structure of NAV1.7 VSD2 (deactived state) in complex with the gating modifier toxin PROTX2electron microscopyB, C, D, A——
6NT3Cryo-EM structure of a human-cockroach hybrid Nav channel.electron microscopyANAG, BMA, Y01, 76F, LHG, AJP—
6NT3Cryo-EM structure of a human-cockroach hybrid nav channel.electron microscopyANAG, BMA, Y01, 76F, LHG, AJP—
6NT4Cryo-EM structure of a human-cockroach hybrid nav channel bound to alpha-scorpion toxin AAH2.electron microscopyANAG, BMA, 76F, AJP, LHG, Y01—
6VXONaChBac-Nav1.7VSDII chimera in nanodiscelectron microscopyA, C, D, EPOV—
6VXONachbac-NAV1.7VSDII chimera in nanodiscelectron microscopyA, C, D, EPOV—
6W6ONachbac-NAV1.7VSDII chimera and hwtx-IV complexelectron microscopyA, D, F, HPOV—
7K48Structure of NAVAB/NAV1.7-VS2A chimera trapped in the resting state by tarantula toxin…electron microscopyA, B, C, D——
7W9KCryo-EM structure of human NAV1.7-BETA1-BETA2 complex at 2.2 ångström resolutionelectron microscopyANAG, Y01, 9Z9, NA, LPE, 1PW—
7W9LCryo-EM structure of human NAV1.7(E406K)-BETA1-BETA2 complexelectron microscopyANAG, Y01, 9Z9, LPE, PCW, P5S—
7W9MCryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, ProTx-II and…electron microscopyANAG, 9SR, P5S, Y01, LPE20 (best 0.86)
7W9MCryo-EM structure of human NAV1.7(E406K) in complex with auxiliary beta subunits, protx-II and…electron microscopyANAG, 9SR, Y01—
7W9PCryo-EM structure of human NAV1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and…electron microscopyANAG, 9SL, Y01, LPE, 1PW, PCW—
7W9TCryo-EM structure of human NAV1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and…electron microscopyANAG, 9SL, Y01, 9Z9, LPE, PCW—
7XVEHuman Nav1.7 mutant class-Ielectron microscopyANAG, Y01, CLR, LPE, 1PW, PCW20 (best 0.86)
7XVEHuman NAV1.7 mutant class-Ielectron microscopyANAG, Y01, CLR, LPE, 1PW, PCW—
7XVFNAV1.7 mutant CLASS2electron microscopyANAG, Y01, CLR, LPE, 1PW, PCW—
8F0SStructure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-9296electron microscopyANAG, BMA, X80, PEE, Y0120 (best 0.87)
8THHCryo-EM structure of Nav1.7 with LTGelectron microscopyANAG, IYJ, Y01, LPE, PCW, P5S20 (best 0.85)
8XMMVoltage-gated sodium channel Nav1.7 variant M9electron microscopyANAG, CLR, LPE, 1PW, PCW, P5S20 (best 0.86)
8XMNVoltage-gated sodium channel Nav1.7 variant M2electron microscopyANAG, LPE, PCW20 (best 0.84)
8XMOVoltage-gated sodium channel Nav1.7 variant M4electron microscopyANAG, LPE, PCW20 (best 0.85)
Q15858AlphaFold monomer V2.0 prediction for sodium channel protein type 9 subunit alpha (Q15858)predictedA—20 (best 0.86)

Ligands

  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 21 records
  • Y01 · Cholesterol hemisuccinate · in 14 records
  • LPE · 1-O-octadecyl-sn-glycero-3-phosphocholine · in 12 records
  • PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 11 records
  • P5S · O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy) propyl]oxy}(hydroxy)phosphoryl]-L-serine · in 8 records
  • 1PW · (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate · in 6 records
  • 9SL · [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate · in 4 records
  • 9SR · (1R,5R,6R,7R,9S,11S,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5, 9,12,13,14-pentol (non-preferred name) · in 4 records
  • BMA · beta-D-mannopyranose · in 4 records
  • CLR · Cholesterol · in 4 records
  • 76F · (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z, 12E)-octadeca-9,12-dienoate · in 3 records
  • 9Z9 · (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en · in 3 records
  • AJP · Digitonin · in 3 records
  • LHG · 1,2-dipalmitoyl-phosphatidyl-glycerole · in 3 records
  • POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 3 records
  • IYJ · (6M)-6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine · in 1 record
  • NA · Sodium ion · in 1 record
  • PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 1 record
  • X80 · 5-chloro-4-(cyclopentylmethoxy)-N-(4-{[(1S,2S)-2-(dimethylamino)cyclohexyl]amino}-2-fluorobenzene-1-sulfonyl)-2-fluorobenzamide · in 1 record

Experiment against prediction

Elsewhere

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