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Ligand · 5P2

5P2 · 3-cyano-4-[2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]-4-(trifluoromethyl)phenoxy]-~{N}-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

5P2, 3-cyano-4-[2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]-4-(trifluoromethyl)phenoxy]-~{N}-(1,2,4-thiadiazol-5-yl)benzenesulfonamide (C24 H20 F3 N7 O3 S2, 575.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
5P2
Formula
C24 H20 F3 N7 O3 S2
Class
ligand
Structures
2
PDB entries
1

Binding sites

5P2 in 2 structures; the first of them:

  • 5EK0 · Human Nav1.7-VSD4-NavAb in complex with GX-936. · 5P2 A1808 · binds GLU1534, TYR1537, TRP1538, ASN1540, VAL1541, ILE1544, SER1578, GLY1581 and 11 more
  • 5EK0 · Human NAV1.7-VSD4-navab in complex with gx-936. · 5P2 A1808 · binds GLU1534, TYR1537, TRP1538, ASN1540, VAL1541, ILE1544, SER1578, GLY1581 and 11 more

Residues it binds most

ARG 8, ALA 8, GLU 8, PHE 8, ILE 8, ASN 8, ASP 8, GLY 8, MET 8, SER 8 (residue and the binding sites it lines).

Found with

  • PX4 · 1,2-dimyristoyl-sn-glycero-3-phosphocholine

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