MolNFT v1 · #421525 · protein
AlphaFold monomer V2.0 prediction for sodium channel protein type 9 subunit alpha (Q15858)
Q15858: “AlphaFold monomer V2.0 prediction for sodium channel protein type 9 subunit alpha (Q15858)”. 20 pockets (best druggability 0.86). MolNFT v1 #421525 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q15858
- Type
- protein
- Length
- 1,988 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x5881B09f2D8e743400698633641fc1cD2Ed2BE6F
- Molecule
- Sodium channel protein type 9 subunit alpha
- UniProt
- Q15858
- Pockets
- 20 · best druggability 0.86
Structure
1 distinct chain · 54% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sodium channel protein type 9 subunit alpha | protein | 1988 | 54% helix, 3% strand | Q15858 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1188 | 0.86 | 0.87 | 106 | empty |
| 2 | 976 | 0.75 | 0.78 | 94 | empty |
| 3 | 581 | 0.73 | 0.80 | 54 | empty |
| 4 | 573 | 0.70 | 0.79 | 54 | empty |
| 5 | 291 | 0.64 | 0.81 | 40 | empty |
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 7W9T · Cryo-EM structure of human NAV1.7(E406K) in complex with auxiliary beta subunits… · an experimental structure of the same protein · chain A against A, TM-score 0.67
- 7W9L · Cryo-EM structure of human NAV1.7(E406K)-BETA1-BETA2 complex · an experimental structure of the same protein · chain A against A, TM-score 0.66
- 7W9P · Cryo-EM structure of human NAV1.7(E406K) in complex with auxiliary beta subunits… · an experimental structure of the same protein · chain A against A, TM-score 0.66
- 7W9K · Cryo-EM structure of human NAV1.7-BETA1-BETA2 complex at 2.2 ångström resolution · an experimental structure of the same protein · chain A against A, TM-score 0.66
- 7W9M · Cryo-EM structure of human NAV1.7(E406K) in complex with auxiliary beta subunits… · an experimental structure of the same protein · chain A against A, TM-score 0.65
- 7W9M · Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits… · an experimental structure of the same protein · chain A against A, TM-score 0.65
- 8XMO · Voltage-gated sodium channel Nav1.7 variant M4 · an experimental structure of the same protein · chain A against A, TM-score 0.64
- 7XVF · NAV1.7 mutant CLASS2 · an experimental structure of the same protein · chain A against A, TM-score 0.62
- 7XVE · Human NAV1.7 mutant class-I · an experimental structure of the same protein · chain A against A, TM-score 0.61
- 7XVE · Human Nav1.7 mutant class-I · an experimental structure of the same protein · chain A against A, TM-score 0.61
- 6NT3 · Cryo-EM structure of a human-cockroach hybrid Nav channel. · an experimental structure of the same protein · chain A against A, TM-score 0.60
- 6NT3 · Cryo-EM structure of a human-cockroach hybrid nav channel. · an experimental structure of the same protein · chain A against A, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15858
- Elsewhere: UniProt Q15858 · AlphaFold DB Q15858
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