UniProt Q07699
Sodium channel subunit beta-1 (Q07699)
Sodium channel subunit beta-1 (UniProt Q07699): 35 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 64 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q07699
- Protein
- Sodium channel subunit beta-1
- Experimental structures
- 35
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 64 · 21 records with a druggable one
Structures
36 records of Q07699 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6AGF | Structure of the human voltage-gated sodium channel NAV1.4 in complex with BETA1 | electron microscopy | B | NAG | — |
| 6J8G | Structure of human voltage-gated sodium channel Nav1.7 in complex with auxiliary beta subunits… | electron microscopy | B | NAG | 2 (best 0.69) |
| 6J8G | Structure of human voltage-gated sodium channel NAV1.7 in complex with auxiliary beta subunits… | electron microscopy | B | NAG | — |
| 6J8H | Structure of human voltage-gated sodium channel NAV1.7 in complex with auxiliary beta subunits… | electron microscopy | B | NAG | — |
| 6J8I | Structure of human voltage-gated sodium channel Nav1.7 in complex with auxiliary beta subunits… | electron microscopy | B | NAG | 3 (best 0.66) |
| 6J8I | Structure of human voltage-gated sodium channel NAV1.7 in complex with auxiliary beta subunits… | electron microscopy | B | NAG | — |
| 6J8J | Structure of human voltage-gated sodium channel NAV1.7 in complex with auxiliary beta subunits… | electron microscopy | B | NAG | — |
| 7W77 | cryo-EM structure of human NaV1.3/beta1/beta2-bulleyaconitineA | electron microscopy | B | NAG | 3 (best 0.73) |
| 7W77 | Cryo-EM structure of human NAV1.3/BETA1/BETA2-bulleyaconitinea | electron microscopy | B | NAG | — |
| 7W7F | Cryo-EM structure of human NAV1.3/BETA1/BETA2-ICA121431 | electron microscopy | B | NAG | — |
| 7W9K | Cryo-EM structure of human Nav1.7-beta1-beta2 complex at 2.2 angstrom resolution | electron microscopy | B | NAG, LPE | 4 (best 0.69) |
| 7W9K | Cryo-EM structure of human NAV1.7-BETA1-BETA2 complex at 2.2 ångström resolution | electron microscopy | B | NAG, LPE | — |
| 7W9L | Cryo-EM structure of human NAV1.7(E406K)-BETA1-BETA2 complex | electron microscopy | B | NAG, LPE | — |
| 7W9M | Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, ProTx-II and… | electron microscopy | B | NAG, LPE | 4 (best 0.72) |
| 7W9M | Cryo-EM structure of human NAV1.7(E406K) in complex with auxiliary beta subunits, protx-II and… | electron microscopy | B | NAG, LPE | — |
| 7W9P | Cryo-EM structure of human NAV1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and… | electron microscopy | B | NAG, LPE | — |
| 7W9T | Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and… | electron microscopy | B | NAG, LPE | 3 (best 0.67) |
| 7W9T | Cryo-EM structure of human NAV1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and… | electron microscopy | B | NAG, LPE | — |
| 7XM9 | Cryo-EM structure of human NaV1.7/beta1/beta2-XEN907 | electron microscopy | B | NAG | 2 (best 0.76) |
| 7XMG | Cryo-EM structure of human NaV1.7/beta1/beta2-TCN-1752 | electron microscopy | B | NAG | 2 (best 0.75) |
| 7XVE | Human Nav1.7 mutant class-I | electron microscopy | B | LPE, NAG | 4 (best 0.86) |
| 7XVE | Human NAV1.7 mutant class-I | electron microscopy | B | LPE, NAG | — |
| 7XVF | NAV1.7 mutant CLASS2 | electron microscopy | B | LPE, NAG | — |
| 8FHD | Cryo-EM structure of human voltage-gated sodium channel Nav1.6 | electron microscopy | C | NAG | 4 (best 0.65) |
| 8G1A | Cryo-EM structure of Nav1.7 with CBD | electron microscopy | B | NAG, LPE | 3 (best 0.66) |
| 8I5G | Structure of human Nav1.7 in complex with PF-05089771 | electron microscopy | B | NAG, LPE | 3 (best 0.68) |
| 8I5X | Structure of human Nav1.7 in complex with Vinpocetine | electron microscopy | B | NAG, LPE | 2 (best 0.74) |
| 8I5Y | Structure of human Nav1.7 in complex with vixotrigine | electron microscopy | B | NAG, LPE | 3 (best 0.69) |
| 8J4F | Structure of human Nav1.7 in complex with Hardwickii acid | electron microscopy | B | NAG, LPE | 3 (best 0.68) |
| 8S9C | Cryo-EM structure of Nav1.7 with CBZ | electron microscopy | B | NAG, LPE | 3 (best 0.68) |
| 8THG | Cryo-EM structure of Nav1.7 with RLZ | electron microscopy | B | NAG | 3 (best 0.68) |
| 8THH | Cryo-EM structure of Nav1.7 with LTG | electron microscopy | B | NAG | 3 (best 0.69) |
| 8XMM | Voltage-gated sodium channel Nav1.7 variant M9 | electron microscopy | B | NAG | 4 (best 0.70) |
| 8XMN | Voltage-gated sodium channel Nav1.7 variant M2 | electron microscopy | B | NAG | 3 (best 0.64) |
| 8XMO | Voltage-gated sodium channel Nav1.7 variant M4 | electron microscopy | B | NAG | 3 (best 0.71) |
| Q07699 | AlphaFold monomer V2.0 prediction for sodium channel subunit beta-1 (Q07699) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8XMM chain B against the predicted model Q07699: TM-score 0.93, RMSD 1.42 Å
- 7W9L chain B against the predicted model Q07699: TM-score 0.93, RMSD 1.43 Å
- 7XVF chain B against the predicted model Q07699: TM-score 0.93, RMSD 1.47 Å
- 7XVE chain B against the predicted model Q07699: TM-score 0.93, RMSD 1.49 Å
- 7XVE chain B against the predicted model Q07699: TM-score 0.93, RMSD 1.49 Å
- 7XMG chain B against the predicted model Q07699: TM-score 0.93, RMSD 1.48 Å
- 8I5Y chain B against the predicted model Q07699: TM-score 0.92, RMSD 1.50 Å
- 8I5G chain B against the predicted model Q07699: TM-score 0.92, RMSD 1.52 Å
- 7W77 chain B against the predicted model Q07699: TM-score 0.92, RMSD 1.49 Å
- 7W77 chain B against the predicted model Q07699: TM-score 0.92, RMSD 1.49 Å
Elsewhere
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