Cryo-EM structure of LTB4-bound BLT1 in complex with gi protein

Structure

electron microscopy · 5 distinct chains.

Ligands and binding sites

• Y01 · Cholesterol hemisuccinate · ligand · 4 copies · chains A
• LTB · Leukotriene B4 · ligand · chains A
• 8IO · [(2R)-2-[(Z)-hexadec-9-enoyl]oxy-3-[oxidanyl-[(2S,3R, 5R,6S)-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propyl] octadecanoate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7VKT · cryo-EM structure of LTB4-bound BLT1 in complex with Gi protein · the same entry in another collection · chain E against E, TM-score 1.00
• P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain C against A, TM-score 0.98
• Q15722 · AlphaFold monomer V2.0 prediction for leukotriene B4 receptor 1 (Q15722) · a predicted model of the same protein · chain A against A, TM-score 0.92
• P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain D against A, TM-score 0.82
• P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain B against A, TM-score 0.81

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q15722
• Every structure of UniProt P63096
• Every structure of UniProt P62873
• Every structure of UniProt P59768
• Elsewhere: RCSB PDB 7VKT · PDBe 7VKT · UniProt Q15722 · UniProt P63096 · UniProt P62873 · UniProt P59768