UniProt Q15722
Leukotriene B4 receptor 1 (Q15722)
Leukotriene B4 receptor 1 (UniProt Q15722): 4 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q15722
- Protein
- Leukotriene B4 receptor 1
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 9 · 2 records with a druggable one
Structures
5 records of Q15722 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7K15 | Crystal structure of the Human Leukotriene B4 Receptor 1 in Complex with Selective Antagonist… | x-ray diffraction | A | VRJ, NA, FMN, OLA | 5 (best 0.78) |
| 7K15 | Crystal structure of the human leukotriene B4 receptor 1 in complex with selective antagonist… | x-ray diffraction | A | VRJ, NA, FMN, OLA | — |
| 7VKT | cryo-EM structure of LTB4-bound BLT1 in complex with Gi protein | electron microscopy | A | LTB, Y01, 8IO | 4 (best 0.80) |
| 7VKT | Cryo-EM structure of LTB4-bound BLT1 in complex with gi protein | electron microscopy | A | LTB, Y01, 8IO | — |
| Q15722 | AlphaFold monomer V2.0 prediction for leukotriene B4 receptor 1 (Q15722) | predicted | A | — | — |
Ligands
- 8IO · [(2R)-2-[(Z)-hexadec-9-enoyl]oxy-3-[oxidanyl-[(2S,3R, 5R,6S)-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propyl] octadecanoate · in 2 records
- FMN · Flavin mononucleotide · in 2 records
- LTB · Leukotriene B4 · in 2 records
- NA · Sodium ion · in 2 records
- OLA · Oleic acid · in 2 records
- VRJ · N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide · in 2 records
- Y01 · Cholesterol hemisuccinate · in 2 records
Experiment against prediction
- 7K15 chain A against the predicted model P00323: TM-score 0.32, RMSD 0.38 Å
- 7K15 chain A against the predicted model P00323: TM-score 0.32, RMSD 0.38 Å
- 7VKT chain A against the predicted model Q15722: TM-score 0.92, RMSD 2.28 Å
- 7VKT chain A against the predicted model Q15722: TM-score 0.92, RMSD 2.28 Å
- 7K15 chain A against the predicted model Q15722: TM-score 0.62, RMSD 2.07 Å
- 7K15 chain A against the predicted model Q15722: TM-score 0.62, RMSD 2.07 Å
Elsewhere
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