MolNFT v1 · #188843 · protein
Human L-type voltage-gated calcium channel CAV1.3 at 3.0 ångström resolution
7UHG · Voltage-dependent L-type calcium channel subunit beta-3: “Human L-type voltage-gated calcium channel CAV1.3 at 3.0 ångström resolution”. Electron microscopy, 4 ligands (CLR, 3PE, NAG), 20 pockets (best druggability 0.85). MolNFT v1…
- PDB
- 7UHG
- Type
- protein
- Length
- 2,502 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Voltage-dependent L-type calcium channel subunit beta-3; Voltage-dependent L-type calcium…
- UniProt
- P54284, Q01668, P54289
- Ligands
- CLR, 3PE, NAG, CA
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 3 distinct chains · 48% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Voltage-dependent L-type calcium channel subunit beta-3 | protein | 324 | 35% helix, 14% strand | P54284 |
| A | Voltage-dependent L-type calcium channel subunit alpha-1D | protein | 1230 | 66% helix, 3% strand | Q01668 |
| D | Voltage-dependent calcium channel subunit alpha-2/DELTA-1 | protein | 948 | 30% helix, 24% strand | P54289 |
Ligands and binding sites
- CLR · Cholesterol · ligand · 3 copies · chains A
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 17 copies · chains A, D
- CA · Calcium ion · metal · 2 copies · chains A, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1050 | 0.85 | 0.85 | 66 | empty |
| 2 | 881 | 0.79 | 0.82 | 99 | empty |
| 3 | 795 | 0.76 | 0.80 | 95 | empty |
| 4 | 844 | 0.75 | 0.79 | 83 | empty |
| 5 | 228 | 0.74 | 0.89 | 36 | empty |
Interfaces
2 interfaces between chains.
- A–D · 1359 Ų buried · 9 hydrogen bonds · protein-protein
- C–A · 1001 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide, 7 glycan (disulfide, N-glycosylation).
Compared structures
- 7UHG · Human L-type voltage-gated calcium channel Cav1.3 at 3.0 Angstrom resolution · the same entry in another collection · chain C against C, TM-score 1.00
- P54289 · AlphaFold monomer V2.0 prediction for voltage-dependent calcium channel subunit… · a predicted model of the same protein · chain D against A, TM-score 1.00
- Q01668 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain A against A, TM-score 0.98
- P54284 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain C against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54284
- Every structure of UniProt Q01668
- Every structure of UniProt P54289
- Elsewhere: RCSB PDB 7UHG · PDBe 7UHG · UniProt P54284 · UniProt Q01668 · UniProt P54289
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