UniProt P54289
Voltage-dependent calcium channel subunit alpha-2/delta-1 (P54289)
Voltage-dependent calcium channel subunit alpha-2/delta-1 (UniProt P54289): 37 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 222 pockets. Binding sites, druggability and experiment against…
- UniProt
- P54289
- Protein
- Voltage-dependent calcium channel subunit alpha-2/delta-1
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 222 · 28 records with a druggable one
Structures
38 records of P54289 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7MIX | Human N-type voltage-gated calcium channel Cav2.2 in the presence of ziconotide at 3.0 Angstrom… | electron microscopy | D | NAG, Y01, CA | 6 (best 0.83) |
| 7MIX | Human N-type voltage-gated calcium channel CAV2.2 in the presence of ziconotide at 3.0 ångström… | electron microscopy | D | NAG, Y01, CA | — |
| 7MIY | Human N-type voltage-gated calcium channel Cav2.2 at 3.1 Angstrom resolution | electron microscopy | D | NAG, Y01, CA | 7 (best 0.79) |
| 7MIY | Human N-type voltage-gated calcium channel CAV2.2 at 3.1 ångström resolution | electron microscopy | D | NAG, CA | — |
| 7UHF | Human L-type voltage-gated calcium channel Cav1.3 in the presence of cinnarizine at 3.1 Angstrom… | electron microscopy | D | NAG, CA | 8 (best 0.77) |
| 7UHF | Human L-type voltage-gated calcium channel CAV1.3 in the presence of cinnarizine at 3.1 ångström… | electron microscopy | D | NAG, CA | — |
| 7UHG | Human L-type voltage-gated calcium channel Cav1.3 at 3.0 Angstrom resolution | electron microscopy | D | NAG, CA | 9 (best 0.79) |
| 7UHG | Human L-type voltage-gated calcium channel CAV1.3 at 3.0 ångström resolution | electron microscopy | D | NAG, CA | — |
| 7VFS | Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, apo state | electron microscopy | B | NAG, BMA, CA | 9 (best 0.77) |
| 7VFS | Human N-type voltage gated calcium channel CAV2.2-ALPHA2/DELTA1-BETA1 complex, apo state | electron microscopy | B | NAG, BMA, CA | — |
| 7VFU | Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to ziconotide | electron microscopy | B | NAG, BMA, CA | 9 (best 0.86) |
| 7VFU | Human N-type voltage gated calcium channel CAV2.2-ALPHA2/DELTA1-BETA1 complex, bound to ziconotide | electron microscopy | B | NAG, BMA, CA | — |
| 7VFV | Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to PD173212 | electron microscopy | B | NAG, BMA, CA | 7 (best 0.78) |
| 7VFV | Human N-type voltage gated calcium channel CAV2.2-ALPHA2/DELTA1-BETA1 complex, bound to PD173212 | electron microscopy | B | NAG, BMA, CA | — |
| 7VFW | Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to… | electron microscopy | B | NAG, BMA, CA | 7 (best 0.78) |
| 7VFW | Human N-type voltage gated calcium channel CAV2.2-ALPHA2/DELTA1-BETA1 complex, bound to… | electron microscopy | B | NAG, BMA, CA | — |
| 7XLQ | Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the… | electron microscopy | D | NAG, BMA, R16, CA | 6 (best 0.77) |
| 7YG5 | Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the… | electron microscopy | D | NAG, BMA, CA | — |
| 8E59 | Human L-type voltage-gated calcium channel Cav1.3 in the presence of Amiodarone at 3.1 Angstrom… | electron microscopy | D | NAG, CA | 9 (best 0.78) |
| 8E5A | Human L-type voltage-gated calcium channel Cav1.3 treated with 1.4 mM Sofosbuvir at 3.3 Angstrom… | electron microscopy | D | NAG, CA | 7 (best 0.78) |
| 8E5B | Human L-type voltage-gated calcium channel Cav1.3 in the presence of Amiodarone and Sofosbuvir at… | electron microscopy | D | NAG, CA | 9 (best 0.78) |
| 8EPL | Human R-type voltage-gated calcium channel Cav2.3 at 3.1 Angstrom resolution | electron microscopy | C | NAG, CA | 7 (best 0.80) |
| 8EPM | Human R-type voltage-gated calcium channel Cav2.3 CH2II-deleted mutant at 3.1 Angstrom resolution | electron microscopy | C | NAG, CA | 10 (best 0.77) |
| 8FHS | Human L-type voltage-gated calcium channel Cav1.2 in the presence of amiodarone and sofosbuvir at… | electron microscopy | D | NAG, CA | 7 (best 0.82) |
| 8HLP | Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 (apo) | electron microscopy | F | NAG | 6 (best 0.75) |
| 8HMA | Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 in complex with… | electron microscopy | F | NAG, BMA | 7 (best 0.75) |
| 8HMB | Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 in complex with… | electron microscopy | E | NAG | 8 (best 0.76) |
| 8IF3 | Structure of human alpha-2/delta-1 with mirogabalin | electron microscopy | A | NAG, 8X9 | 14 (best 0.79) |
| 8IF4 | Structure of human alpha-2/delta-1 without mirogabalin | electron microscopy | A | NAG | 9 (best 0.78) |
| 8WE6 | Human L-type voltage-gated calcium channel Cav1.2 at 2.9 Angstrom resolution | electron microscopy | D | NAG, CA | 7 (best 0.83) |
| 8WE7 | Human L-type voltage-gated calcium channel Cav1.2 in the presence of calciseptine at 3.2 Angstrom… | electron microscopy | D | NAG, CA | 8 (best 0.79) |
| 8WE8 | Human L-type voltage-gated calcium channel Cav1.2 in the presence of calciseptine, amlodipine and… | electron microscopy | D | NAG, CA | 9 (best 0.79) |
| 8WE9 | Human L-type voltage-gated calcium channel Cav1.2 (Class I) in the presence of pinaverium at 3.0… | electron microscopy | D | NAG, CA | 8 (best 0.78) |
| 8WEA | Human L-type voltage-gated calcium channel Cav1.2 (Class II) in the presence of pinaverium at 3.2… | electron microscopy | D | NAG, CA | 10 (best 0.78) |
| 8X90 | P/Q type calcium channel | electron microscopy | B | NAG, Y01, CA | 6 (best 0.82) |
| 8X91 | P/Q type calcium channel in complex with omega-conotoxin MVIIC | electron microscopy | B | NAG, CA, Y01 | 6 (best 0.82) |
| 8X93 | P/Q type calcium channel in complex with omega-Agatoxin IVA | electron microscopy | B | NAG, CA, Y01 | 7 (best 0.79) |
| P54289 | AlphaFold monomer V2.0 prediction for voltage-dependent calcium channel subunit alpha-2/DELTA-1… | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 37 records
- CA · Calcium ion · in 32 records
- BMA · beta-D-mannopyranose · in 11 records
- Y01 · Cholesterol hemisuccinate · in 6 records
- 8X9 · 2-[(1R,5S,6S)-6-(aminomethyl)-3-ethyl-6-bicyclo[3.2.0]hept-3-enyl]acetic acid · in 1 record
- R16 · Hexadecane · in 1 record
Experiment against prediction
- 8HMB chain E against the predicted model P54289: TM-score 1.00, RMSD 0.71 Å
- 8WE6 chain D against the predicted model P54289: TM-score 1.00, RMSD 0.75 Å
- 7MIX chain D against the predicted model P54289: TM-score 0.99, RMSD 0.75 Å
- 7MIX chain D against the predicted model P54289: TM-score 0.99, RMSD 0.75 Å
- 7UHG chain D against the predicted model P54289: TM-score 0.99, RMSD 0.74 Å
- 7UHG chain D against the predicted model P54289: TM-score 0.99, RMSD 0.74 Å
- 8E59 chain D against the predicted model P54289: TM-score 0.99, RMSD 0.75 Å
- 8E5A chain D against the predicted model P54289: TM-score 0.99, RMSD 0.76 Å
- 8HMA chain F against the predicted model P54289: TM-score 0.99, RMSD 0.75 Å
- 7MIY chain D against the predicted model P54289: TM-score 0.99, RMSD 0.77 Å
Elsewhere
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