MolNFT v1 · #189435 · protein
Human N-type voltage gated calcium channel CAV2.2-ALPHA2/DELTA1-BETA1 complex, apo state
7VFS: “Human N-type voltage gated calcium channel CAV2.2-ALPHA2/DELTA1-BETA1 complex, apo state”. Electron microscopy, 6 ligands (R16, Y01, PT5). MolNFT v1 #189435 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7VFS
- Type
- protein
- Length
- 2,383 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q00975, P54289, Q02641
- Ligands
- R16, Y01, PT5, NAG, BMA, CA
Structure
electron microscopy · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 1266 | — | Q00975 |
| B | — | protein | 955 | — | P54289 |
| D | — | protein | 162 | — | Q02641 |
Ligands and binding sites
- R16 · Hexadecane · ligand · 18 copies · chains A
- Y01 · Cholesterol hemisuccinate · ligand · 3 copies · chains A
- PT5 · (1S)-2-{[(R)-hydroxy{[(1r,2r,3s,4r,5r,6s)-2,3,6-trihydroxy-4,5-bis(phosphonooxy) cyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy) methyl]ethyl (8E,11E)-icosa-5,8,11,14-tetraenoate · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 14 copies · chains B
- BMA · beta-D-mannopyranose · sugar · 3 copies · chains B
- CA · Calcium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7VFS · Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, apo state · the same entry in another collection · chain A against A, TM-score 1.00
- P54289 · AlphaFold monomer V2.0 prediction for voltage-dependent calcium channel subunit… · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q02641 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain D against A, TM-score 0.98
- Q00975 · AlphaFold monomer V2.0 prediction for voltage-dependent N-type calcium channel subunit… · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00975
- Every structure of UniProt P54289
- Every structure of UniProt Q02641
- Elsewhere: RCSB PDB 7VFS · PDBe 7VFS · UniProt Q00975 · UniProt P54289 · UniProt Q02641
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.