UniProt Q00975
Voltage-dependent N-type calcium channel subunit alpha-1B (Q00975)
Voltage-dependent N-type calcium channel subunit alpha-1B (UniProt Q00975): 11 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 46 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q00975
- Protein
- Voltage-dependent N-type calcium channel subunit alpha-1B
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 46 · 3 records with a druggable one
Structures
12 records of Q00975 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2LCM | NMR structure of S3-4 peptide | solution nmr | A | — | — |
| 2LCM | NMR structure of S3-4 peptide | solution nmr | A | — | — |
| 7MIX | Human N-type voltage-gated calcium channel Cav2.2 in the presence of ziconotide at 3.0 Angstrom… | electron microscopy | A | NAG, CA, Y01, CLR, 3PE, PT5 | 15 (best 0.84) |
| 7MIX | Human N-type voltage-gated calcium channel CAV2.2 in the presence of ziconotide at 3.0 ångström… | electron microscopy | A | NAG, CA, Y01, CLR, 3PE, PT5 | — |
| 7MIY | Human N-type voltage-gated calcium channel Cav2.2 at 3.1 Angstrom resolution | electron microscopy | A | NAG, CA, Y01, CLR, 3PE, PT5 | 16 (best 0.85) |
| 7MIY | Human N-type voltage-gated calcium channel CAV2.2 at 3.1 ångström resolution | electron microscopy | A | NAG, CA, Y01, CLR, 3PE, PT5 | — |
| 7VFS | Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, apo state | electron microscopy | A | R16, Y01, PT5, CA | 15 (best 0.86) |
| 7VFS | Human N-type voltage gated calcium channel CAV2.2-ALPHA2/DELTA1-BETA1 complex, apo state | electron microscopy | A | R16, Y01, PT5, CA | — |
| 7VFU | Human N-type voltage gated calcium channel CAV2.2-ALPHA2/DELTA1-BETA1 complex, bound to ziconotide | electron microscopy | A | R16, Y01, PT5, CA | — |
| 7VFV | Human N-type voltage gated calcium channel CAV2.2-ALPHA2/DELTA1-BETA1 complex, bound to PD173212 | electron microscopy | A | R16, Y01, PT5, 6IX, CA | — |
| 7VFW | Human N-type voltage gated calcium channel CAV2.2-ALPHA2/DELTA1-BETA1 complex, bound to… | electron microscopy | A | R16, Y01, PT5, 6I7, CA | — |
| Q00975 | AlphaFold monomer V2.0 prediction for voltage-dependent N-type calcium channel subunit alpha-1B… | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 9 records
- PT5 · (1S)-2-{[(R)-hydroxy{[(1r,2r,3s,4r,5r,6s)-2,3,6-trihydroxy-4,5-bis(phosphonooxy) cyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy) methyl]ethyl (8E,11E)-icosa-5,8,11,14-tetraenoate · in 9 records
- Y01 · Cholesterol hemisuccinate · in 9 records
- R16 · Hexadecane · in 5 records
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 4 records
- CLR · Cholesterol · in 4 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- 6I7 · 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazole · in 1 record
- 6IX · (2~{S})-~{N}-[(2~{S})-1-(~{tert}-butylamino)-1-oxidanylidene-3-(4-phenylmethoxyphenyl)propan-2-yl]-2-[(4-~{tert}-butylphenyl)methyl-methyl-amino]-4-methyl-pentanamide · in 1 record
Experiment against prediction
- 7VFV chain A against the predicted model Q00975: TM-score 0.93, RMSD 2.84 Å
- 7VFW chain A against the predicted model Q00975: TM-score 0.93, RMSD 2.84 Å
- 7VFS chain A against the predicted model Q00975: TM-score 0.93, RMSD 2.94 Å
- 7VFS chain A against the predicted model Q00975: TM-score 0.93, RMSD 2.94 Å
- 7VFU chain A against the predicted model Q00975: TM-score 0.93, RMSD 2.89 Å
- 7MIY chain A against the predicted model Q00975: TM-score 0.93, RMSD 3.08 Å
- 7MIY chain A against the predicted model Q00975: TM-score 0.93, RMSD 3.08 Å
- 7MIX chain A against the predicted model Q00975: TM-score 0.92, RMSD 3.17 Å
- 7MIX chain A against the predicted model Q00975: TM-score 0.92, RMSD 3.17 Å
- 2LCM chain A against the predicted model Q00975: TM-score 0.52, RMSD 1.86 Å
Elsewhere
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