MolNFT v1 · #188050 · protein
M22 agonist autoantibody bound to human thyrotropin receptor in complex with MINIGS399 (composite structure)
7T9N: “M22 agonist autoantibody bound to human thyrotropin receptor in complex with MINIGS399 (composite structure)”. Electron microscopy, 2 ligands (Z41, NAG). MolNFT v1 #188050 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7T9N
- Type
- protein
- Length
- 1,723 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- A0A0A0MTJ0, P63092, P62873, P59768
- Ligands
- Z41, NAG
Structure
electron microscopy · 7 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | — | protein | 212 | — | — |
| H | — | protein | 215 | — | — |
| N | — | protein | 126 | — | — |
| R | — | protein | 555 | — | A0A0A0MTJ0 |
| X | — | protein | 221 | — | P63092 |
| Y | — | protein | 338 | — | P62873 |
| Z | — | protein | 56 | — | P59768 |
Ligands and binding sites
- Z41 · (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate · ligand · chains R
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7T9N · M22 Agonist Autoantibody bound to Human Thyrotropin receptor in complex with miniGs399… · the same entry in another collection · chain Z against Z, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain Y against A, TM-score 1.00
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain Z against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0A0MTJ0
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 7T9N · PDBe 7T9N · UniProt A0A0A0MTJ0 · UniProt P63092 · UniProt P62873 · UniProt P59768
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