Research workbench
M22 agonist autoantibody bound to human thyrotropin receptor in complex with MINIGS399 (composite structure)
Analyse M22 agonist autoantibody bound to human thyrotropin receptor in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7T9N
- Type
- protein
- Length
- 1,723 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- A0A0A0MTJ0, P63092, P62873, P59768
- Ligands
- Z41, NAG
Structure
electron microscopy · 7 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | — | protein | 212 | — | — |
| H | — | protein | 215 | — | — |
| N | — | protein | 126 | — | — |
| R | — | protein | 555 | — | A0A0A0MTJ0 |
| X | — | protein | 221 | — | P63092 |
| Y | — | protein | 338 | — | P62873 |
| Z | — | protein | 56 | — | P59768 |
Ligands and binding sites
- Z41 · (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate · ligand · chains R
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7T9N · M22 Agonist Autoantibody bound to Human Thyrotropin receptor in complex with miniGs399… · the same entry in another collection · chain Z against Z, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain Y against A, TM-score 1.00
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain Z against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0A0MTJ0
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 7T9N · PDBe 7T9N · UniProt A0A0A0MTJ0 · UniProt P63092 · UniProt P62873 · UniProt P59768
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