MolNFT v1 · #187773 · protein
The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (cftr) with ATP/MG and tezacaftor (vx-661)
7SV7: “The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (cftr) with ATP/MG…”. Electron microscopy, 7 ligands (D12, ATP, CLR). MolNFT v1 #187773 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7SV7
- Type
- protein
- Length
- 1,190 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P13569
- Ligands
- D12, ATP, CLR, C14, PJ8, CV6, MG
Structure
electron microscopy · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 1173 | — | P13569 |
| B | — | protein | 17 | — | — |
Ligands and binding sites
- D12 · Dodecane · ligand · 4 copies · chains A
- ATP · Adenosine-5'-triphosphate · ligand · 2 copies · chains A
- CLR · Cholesterol · ligand · 2 copies · chains A
- C14 · Tetradecane · ligand · chains A
- PJ8 · heptadecane · ligand · chains A
- CV6 · Tezacaftor · ligand · chains A
- MG · Magnesium ion · metal · 2 copies · chains A
- DD9 · nonane · additive · 2 copies
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7SV7 · The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator… · the same entry in another collection · chain A against A, TM-score 1.00
- P13569 · AlphaFold monomer V2.0 prediction for cystic fibrosis transmembrane conductance regulator… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13569
- Elsewhere: RCSB PDB 7SV7 · PDBe 7SV7 · UniProt P13569
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