The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (cftr) with ATP/MG and tezacaftor (vx-661)

Structure

electron microscopy · 2 distinct chains.

Ligands and binding sites

• D12 · Dodecane · ligand · 4 copies · chains A
• ATP · Adenosine-5'-triphosphate · ligand · 2 copies · chains A
• CLR · Cholesterol · ligand · 2 copies · chains A
• C14 · Tetradecane · ligand · chains A
• PJ8 · heptadecane · ligand · chains A
• CV6 · Tezacaftor · ligand · chains A
• MG · Magnesium ion · metal · 2 copies · chains A
• DD9 · nonane · additive · 2 copies

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7SV7 · The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator… · the same entry in another collection · chain A against A, TM-score 1.00
• P13569 · AlphaFold monomer V2.0 prediction for cystic fibrosis transmembrane conductance regulator… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P13569
• Elsewhere: RCSB PDB 7SV7 · PDBe 7SV7 · UniProt P13569