Ligand · CV6
CV6 · Tezacaftor
CV6, Tezacaftor (C26 H25 F3 N2 O6, 518.5 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.
- Component
- CV6
- Formula
- C26 H25 F3 N2 O6
- Class
- ligand
- Structures
- 3
- PDB entries
- 2
Binding sites
CV6 in 3 structures; the first of them:
- 7SV7 · The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator… · CV6 A1515 · binds ILE70, ASN71, LEU73, ARG74, PHE77, PHE78, PHE81, MET152 and 7 more
- 8EIQ · The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance… · CV6 A1509 · binds ILE70, ASN71, LEU73, ARG74, PHE77, PHE78, PHE81, MET152 and 8 more
- 7SV7 · The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator… · CV6 A1515 · binds ILE70, ASN71, ARG74, PHE77, PHE78, PHE81, MET152, LEU195 and 5 more
Residues it binds most
PHE 3, LEU 3, ILE 3, ALA 3, ARG 3, ASN 3, MET 3, SER 3, THR 3, TRP 3 (residue and the binding sites it lines).
Found with
- ATP · Adenosine-5'-triphosphate
- CLR · Cholesterol
- D12 · Dodecane
- MG · Magnesium ion
- C14 · Tetradecane
- PJ8 · heptadecane
- DD9 · nonane
- VX7 · N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
- WJX · (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide
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