WJX · (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide

Binding sites

WJX in 2 structures; the first of them:

• 8EIO · The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance… · WJX A1508 · binds SER18, ARG21, LEU24, ARG25, ILE132, LEU1029, TYR1032, TRP1098 and 5 more
• 8EIQ · The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance… · WJX A1508 · binds SER18, ARG21, LEU24, ARG25, ILE132, LEU1029, TYR1032, TRP1098 and 5 more

Residues it binds most

ARG 2, ILE 2, LEU 2, MET 2, SER 2, TRP 2, TYR 2, VAL 2 (residue and the binding sites it lines).

Found with

• ATP · Adenosine-5'-triphosphate
• CLR · Cholesterol
• D12 · Dodecane
• MG · Magnesium ion
• CV6 · Tezacaftor
• VX7 · N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
• VX8 · Lumacaftor