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Ligand · VX8

VX8 · Lumacaftor

VX8, Lumacaftor (C24 H18 F2 N2 O5, 452.4 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
VX8
Formula
C24 H18 F2 N2 O5
Class
ligand
Structures
3
PDB entries
2

Binding sites

VX8 in 3 structures; the first of them:

  • 7SVD · The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator… · VX8 A1511 · binds LYS68, ILE70, LEU73, ARG74, PHE77, PHE78, PHE81, MET152 and 6 more
  • 7SVD · The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator… · VX8 A1511 · binds LYS68, ILE70, LEU73, ARG74, PHE77, PHE78, PHE81, MET152 and 6 more
  • 7SVR · The complex of dephosphorylated human cystic fibrosis transmembrane conductance regulator… · VX8 A1501 · binds LYS68, ILE70, ARG74, PHE78, PHE81, MET152, GLY194, LEU195 and 4 more

Residues it binds most

PHE 3, LEU 3, ALA 3, ARG 3, ILE 3, LYS 3, MET 3, SER 3, THR 3, TRP 3 (residue and the binding sites it lines).

Found with

  • ATP · Adenosine-5'-triphosphate
  • CLR · Cholesterol
  • D10 · Decane
  • D12 · Dodecane
  • MG · Magnesium ion
  • UNX · Unknown atom or ion

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