MolNFT v1 · #184070 · protein
Active state GLUA1/A2 AMPA receptor in complex with tarp gamma 8 and CNIH2 (lbd-tmd)
7OCF: “Active state GLUA1/A2 AMPA receptor in complex with tarp gamma 8 and CNIH2 (lbd-tmd)”. Electron microscopy, 2 ligands (PC1, CYZ). MolNFT v1 #184070 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7OCF
- Type
- protein
- Length
- 2,298 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P19490, P19491, Q5BJU5, Q8VHW5
- Ligands
- PC1, CYZ
Structure
electron microscopy · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | — | protein | 407 | — | P19490 |
| B, D | — | protein | 400 | — | P19491 |
| G, E | — | protein | 158 | — | Q5BJU5 |
| I, J | — | protein | 184 | — | Q8VHW5 |
Ligands and binding sites
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · ligand · 26 copies · chains A, G, B, I, C, E, D, J
- CYZ · Cyclothiazide · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7OCF · Active state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD) · the same entry in another collection · chain G against G, TM-score 1.00
- Q8VHW5 · AlphaFold monomer V2.0 prediction for voltage-dependent calcium channel gamma-8 subunit… · a predicted model of the same protein · chain I against A, TM-score 0.94
- Q5BJU5 · AlphaFold monomer V2.0 prediction for protein cornichon homolog 2 (Q5BJU5) · a predicted model of the same protein · chain G against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19490
- Every structure of UniProt P19491
- Every structure of UniProt Q5BJU5
- Every structure of UniProt Q8VHW5
- Elsewhere: RCSB PDB 7OCF · PDBe 7OCF · UniProt P19490 · UniProt P19491 · UniProt Q5BJU5 · UniProt Q8VHW5
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