UniProt Q8VHW5
Voltage-dependent calcium channel gamma-8 subunit (Q8VHW5)
Voltage-dependent calcium channel gamma-8 subunit (UniProt Q8VHW5): 20 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 41 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8VHW5
- Protein
- Voltage-dependent calcium channel gamma-8 subunit
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 41 · 12 records with a druggable one
Structures
21 records of Q8VHW5 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6QKC | GluA1/2 In complex with auxiliary subunit gamma-8 | electron microscopy | I, J | — | 4 (best 0.75) |
| 6QKC | GLUA1/2 in complex with auxiliary subunit gamma-8 | electron microscopy | I, J | — | — |
| 6QKZ | Full length GluA1/2-gamma8 complex | electron microscopy | I, J | — | 2 (best 0.52) |
| 6QKZ | Full length GLUA1/2-GAMMA8 complex | electron microscopy | I, J | — | — |
| 7OCA | Resting state full-length GluA1/A2 heterotertramer in complex with TARP gamma 8 and CNIH2 | electron microscopy | I, J | PC1 | 2 (best 0.70) |
| 7OCA | Resting state full-length GLUA1/A2 heterotertramer in complex with tarp gamma 8 and CNIH2 | electron microscopy | I, J | PC1 | — |
| 7OCD | Resting state GluA1/A2 heterotetramer in complex with auxiliary subunit TARP gamma 8 (LBD-TMD) | electron microscopy | I, J | — | 2 (best 0.59) |
| 7OCD | Resting state GLUA1/A2 heterotetramer in complex with auxiliary subunit tarp gamma 8 (lbd-tmd) | electron microscopy | I, J | — | — |
| 7OCE | Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD) | electron microscopy | I, J | PC1 | 3 (best 0.69) |
| 7OCE | Resting state GLUA1/A2 AMPA receptor in complex with tarp gamma 8 and CNIH2 (lbd-tmd) | electron microscopy | I, J | PC1 | — |
| 7OCF | Active state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD) | electron microscopy | I, J | PC1 | 3 (best 0.70) |
| 7OCF | Active state GLUA1/A2 AMPA receptor in complex with tarp gamma 8 and CNIH2 (lbd-tmd) | electron microscopy | I, J | PC1 | — |
| 7QHB | Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ | electron microscopy | I, J | PAM | 3 (best 0.71) |
| 7QHB | Active state of GLUA1/2 in complex with tarp gamma 8, L-glutamate and ctz | electron microscopy | I, J | PAM | — |
| 7QHH | Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD) | electron microscopy | J, I | PAM | 3 (best 0.62) |
| 7QHH | Desensitized state of GLUA1/2 AMPA receptor in complex with tarp-gamma 8 (tmd-lbd) | electron microscopy | J, I | PAM | — |
| 8AYL | Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059 | electron microscopy | J, I | POV, OIJ, PLM | 5 (best 0.73) |
| 8AYM | Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-55511118 | electron microscopy | I, J | XVD, PLM, POV | 5 (best 0.73) |
| 8AYN | Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand LY3130481 | electron microscopy | I, J | POV, PLM, OLR | 4 (best 0.74) |
| 8AYO | Open state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059 | electron microscopy | I, J | POV, PLM, OIJ | 5 (best 0.66) |
| Q8VHW5 | AlphaFold monomer V2.0 prediction for voltage-dependent calcium channel gamma-8 subunit (Q8VHW5) | predicted | A | — | — |
Ligands
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 6 records
- PAM · Palmitoleic acid · in 4 records
- PLM · Palmitic acid · in 4 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 4 records
- OIJ · 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one · in 2 records
- OLR · 6-[(1~{S})-1-[1-[5-(2-hydroxyethyloxy)pyridin-2-yl]pyrazol-3-yl]ethyl]-3~{H}-1,3-benzothiazol-2-one · in 1 record
- XVD · 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol · in 1 record
Experiment against prediction
- 7OCD chain I against the predicted model Q8VHW5: TM-score 0.97, RMSD 0.93 Å
- 7OCD chain I against the predicted model Q8VHW5: TM-score 0.97, RMSD 0.93 Å
- 7OCD chain J against the predicted model Q8VHW5: TM-score 0.97, RMSD 0.93 Å
- 7OCD chain J against the predicted model Q8VHW5: TM-score 0.97, RMSD 0.93 Å
- 7OCA chain I against the predicted model Q8VHW5: TM-score 0.96, RMSD 1.28 Å
- 7OCA chain I against the predicted model Q8VHW5: TM-score 0.96, RMSD 1.28 Å
- 7OCE chain I against the predicted model Q8VHW5: TM-score 0.96, RMSD 1.28 Å
- 7OCE chain I against the predicted model Q8VHW5: TM-score 0.96, RMSD 1.28 Å
- 7OCE chain J against the predicted model Q8VHW5: TM-score 0.96, RMSD 1.28 Å
- 7OCE chain J against the predicted model Q8VHW5: TM-score 0.96, RMSD 1.28 Å
Elsewhere
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