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Ligand · OIJ

OIJ · 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one

OIJ, 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one (C25 H22 F N5 O2, 443.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (2 PDB entries). Every binding site with…

Component
OIJ
Formula
C25 H22 F N5 O2
Class
ligand
Structures
2
PDB entries
2

Binding sites

OIJ in 2 structures; the first of them:

  • 8AYL · Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059 · OIJ J501 · binds MET35, TRP44, ASN172, VAL176, ILE180, TYR201, PHE205, TYR206 and 8 more
  • 8AYO · Open state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059 · OIJ I1802 · binds TYR519, GLU520, MET523, CYS524, PHE527, MET35, TRP44, ASN172 and 9 more

Residues it binds most

TYR 4, GLY 4, MET 4, PHE 4, ILE 4, ASN 4, CYS 4, GLU 4, LEU 4, TRP 4 (residue and the binding sites it lines).

Found with

  • PLM · Palmitic acid
  • POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
  • OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
  • CYZ · Cyclothiazide
  • GLU · Glutamic acid
  • ZK1 · {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid

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