MolNFT v1 · #185831 · protein
Desensitized state of GLUA1/2 AMPA receptor in complex with tarp-gamma 8 (tmd-lbd)
7QHH: “Desensitized state of GLUA1/2 AMPA receptor in complex with tarp-gamma 8 (tmd-lbd)”. Electron microscopy, 2 ligands (PAM, 79N). MolNFT v1 #185831 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7QHH
- Type
- protein
- Length
- 1,982 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P19490, P19491, Q8VHW5
- Ligands
- PAM, 79N
Structure
electron microscopy · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | — | protein | 401 | — | P19490 |
| B, D | — | protein | 405 | — | P19491 |
| J, I | — | protein | 185 | — | Q8VHW5 |
Ligands and binding sites
- PAM · Palmitoleic acid · ligand · 10 copies · chains A, B, C, D, J, I
- 79N · (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate · ligand · 2 copies · chains B, C, A, D
- OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7QHH · Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD) · the same entry in another collection · chain I against I, TM-score 1.00
- Q8VHW5 · AlphaFold monomer V2.0 prediction for voltage-dependent calcium channel gamma-8 subunit… · a predicted model of the same protein · chain J against A, TM-score 0.94
- P19491 · AlphaFold monomer V2.0 prediction for glutamate receptor 2 (P19491) · a predicted model of the same protein · chain D against A, TM-score 0.86
- P19490 · AlphaFold monomer V2.0 prediction for glutamate receptor 1 (P19490) · a predicted model of the same protein · chain C against A, TM-score 0.63
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19490
- Every structure of UniProt P19491
- Every structure of UniProt Q8VHW5
- Elsewhere: RCSB PDB 7QHH · PDBe 7QHH · UniProt P19490 · UniProt P19491 · UniProt Q8VHW5
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