UniProt P19490
Glutamate receptor 1 flip isoform (P19490)
Glutamate receptor 1 flip isoform (UniProt P19490): 22 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 132 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P19490
- Protein
- Glutamate receptor 1 flip isoform
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 132 · 8 records with a druggable one
Structures
23 records of P19490 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3SAJ | Crystal Structure of glutamate receptor GluA1 Amino Terminal Domain | x-ray diffraction | A, B, C, D | — | — |
| 3SAJ | Crystal structure of glutamate receptor GLUA1 amino terminal domain | x-ray diffraction | A, B, C, D | — | — |
| 6NJL | Architecture and subunit arrangement of native AMPA receptors | electron microscopy | A, C | NAG, ZK1 | 12 (best 0.82) |
| 6NJL | Architecture and subunit arrangement of native AMPA receptors | electron microscopy | A, C | NAG, ZK1 | — |
| 6NJN | Architecture and subunit arrangement of native AMPA receptors | electron microscopy | A | NAG, ZK1 | — |
| 6QKC | GLUA1/2 in complex with auxiliary subunit gamma-8 | electron microscopy | A, C | E2Q | — |
| 6QKZ | Full length GLUA1/2-GAMMA8 complex | electron microscopy | A, C | NAG, E2Q | — |
| 7OCA | Resting state full-length GluA1/A2 heterotertramer in complex with TARP gamma 8 and CNIH2 | electron microscopy | A, C | NAG, E2Q, PC1 | 17 (best 0.82) |
| 7OCA | Resting state full-length GLUA1/A2 heterotertramer in complex with tarp gamma 8 and CNIH2 | electron microscopy | A, C | NAG, E2Q, PC1 | — |
| 7OCC | Ntd of resting state GLUA1/A2 heterotertramer | electron microscopy | A, C | NAG | — |
| 7OCD | Resting state GluA1/A2 heterotetramer in complex with auxiliary subunit TARP gamma 8 (LBD-TMD) | electron microscopy | A, C | E2Q, PC1 | 16 (best 0.81) |
| 7OCD | Resting state GLUA1/A2 heterotetramer in complex with auxiliary subunit tarp gamma 8 (lbd-tmd) | electron microscopy | A, C | E2Q, PC1 | — |
| 7OCE | Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD) | electron microscopy | A, C | E2Q, PC1 | 20 (best 0.83) |
| 7OCE | Resting state GLUA1/A2 AMPA receptor in complex with tarp gamma 8 and CNIH2 (lbd-tmd) | electron microscopy | A, C | E2Q, PC1 | — |
| 7OCF | Active state GLUA1/A2 AMPA receptor in complex with tarp gamma 8 and CNIH2 (lbd-tmd) | electron microscopy | A, C | CYZ, PC1 | — |
| 7QHB | Active state of GLUA1/2 in complex with tarp gamma 8, L-glutamate and ctz | electron microscopy | A, C | PAM, CYZ, 79N | — |
| 7QHH | Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD) | electron microscopy | A, C | GLU, PAM, 79N | 16 (best 0.86) |
| 7QHH | Desensitized state of GLUA1/2 AMPA receptor in complex with tarp-gamma 8 (tmd-lbd) | electron microscopy | A, C | PAM, 79N | — |
| 8AYM | Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-55511118 | electron microscopy | C, A | XVD, PLM, ZK1, POV | 18 (best 0.83) |
| 8C2I | Transmembrane domain of resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3 | electron microscopy | A, B, C, D | PLM, POV | — |
| 8P3T | Homomeric GluA1 in tandem with TARP gamma-3, desensitized conformation 1 | electron microscopy | A, B, C, D | — | 18 (best 0.83) |
| 8P3V | Homomeric GluA1 in tandem with TARP gamma-3, desensitized conformation 3 | electron microscopy | A, B, C, D | — | 15 (best 0.80) |
| P19490 | AlphaFold monomer V2.0 prediction for glutamate receptor 1 (P19490) | predicted | A | — | — |
Ligands
- E2Q · 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide · in 8 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 7 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 7 records
- ZK1 · {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid · in 4 records
- 79N · (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate · in 3 records
- PAM · Palmitoleic acid · in 3 records
- CYZ · Cyclothiazide · in 2 records
- PLM · Palmitic acid · in 2 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 2 records
- GLU · Glutamic acid · in 1 record
- XVD · 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol · in 1 record
Experiment against prediction
- 7OCC chain A against the predicted model P19490: TM-score 0.97, RMSD 1.32 Å
- 7OCC chain C against the predicted model P19490: TM-score 0.97, RMSD 1.32 Å
- 3SAJ chain B against the predicted model P19490: TM-score 0.96, RMSD 1.47 Å
- 3SAJ chain B against the predicted model P19490: TM-score 0.96, RMSD 1.47 Å
- 3SAJ chain D against the predicted model P19490: TM-score 0.96, RMSD 1.63 Å
- 3SAJ chain D against the predicted model P19490: TM-score 0.96, RMSD 1.63 Å
- 3SAJ chain A against the predicted model P19490: TM-score 0.94, RMSD 1.78 Å
- 3SAJ chain A against the predicted model P19490: TM-score 0.94, RMSD 1.78 Å
- 3SAJ chain C against the predicted model P19490: TM-score 0.93, RMSD 1.93 Å
- 3SAJ chain C against the predicted model P19490: TM-score 0.93, RMSD 1.93 Å
Elsewhere
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