Structures of human ghrelin receptor-gi complexes with ghrelin and a synthetic agonist

Structure

electron microscopy · 5 distinct chains.

Ligands and binding sites

• 1KD · 1-(methanesulfonyl)-1'-(2-methyl-L-alanyl-O-benzyl-D-seryl)-1,2-dihydrospiro[indole-3,4'-piperidine] · ligand · chains R
• CLR · Cholesterol · ligand · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7NA8 · Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist · the same entry in another collection · chain R against R, TM-score 1.00
• P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
• P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.96
• Q92847 · AlphaFold monomer V2.0 prediction for growth hormone secretagogue receptor type 1 (Q92847) · a predicted model of the same protein · chain R against A, TM-score 0.93
• P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.82

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P63096
• Every structure of UniProt P62873
• Every structure of UniProt P59768
• Every structure of UniProt Q92847
• Elsewhere: RCSB PDB 7NA8 · PDBe 7NA8 · UniProt P63096 · UniProt P62873 · UniProt P59768 · UniProt Q92847