UniProt Q92847
Growth hormone secretagogue receptor type 1 (Q92847)
Growth hormone secretagogue receptor type 1 (UniProt Q92847): 10 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 28 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q92847
- Protein
- Growth hormone secretagogue receptor type 1
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 28 · 5 records with a druggable one
Structures
11 records of Q92847 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6KO5 | Complex structure of Ghrelin receptor with Fab | x-ray diffraction | A | 8QX | 5 (best 0.75) |
| 6KO5 | Complex structure of ghrelin receptor with Fab | x-ray diffraction | A | 8QX | — |
| 7F83 | Crystal Structure of a receptor in Complex with inverse agonist | x-ray diffraction | A, B | 1KQ | 9 (best 0.82) |
| 7F83 | Crystal structure of a receptor in complex with inverse agonist | x-ray diffraction | A, B | 1KQ | — |
| 7NA7 | Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist | electron microscopy | R | CLR | 6 (best 0.79) |
| 7NA7 | Structures of human ghrelin receptor-gi complexes with ghrelin and a synthetic agonist | electron microscopy | R | CLR | — |
| 7NA8 | Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist | electron microscopy | R | 1KD, CLR | 2 (best 0.81) |
| 7NA8 | Structures of human ghrelin receptor-gi complexes with ghrelin and a synthetic agonist | electron microscopy | R | 1KD, CLR | — |
| 7W2Z | Cryo-EM structure of the ghrelin-bound human ghrelin receptor-Go complex | electron microscopy | R | CLR | 6 (best 0.81) |
| 7W2Z | Cryo-EM structure of the ghrelin-bound human ghrelin receptor-go complex | electron microscopy | R | K4Q, CLR | — |
| Q92847 | AlphaFold monomer V2.0 prediction for growth hormone secretagogue receptor type 1 (Q92847) | predicted | A | — | — |
Ligands
- CLR · Cholesterol · in 6 records
- 1KD · 1-(methanesulfonyl)-1'-(2-methyl-L-alanyl-O-benzyl-D-seryl)-1,2-dihydrospiro[indole-3,4'-piperidine] · in 2 records
- 1KQ · 2-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)-1-[2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonan-7-yl]ethanone · in 2 records
- 8QX · 6-(4-bromanyl-2-fluoranyl-phenoxy)-2-methyl-3-[[(3~{S})-1-propan-2-ylpiperidin-3-yl]methyl]pyrido[3, 2-d]pyrimidin-4-one · in 2 records
- K4Q · [(2~{S})-2-azanyl-3-oxidanylidene-propyl] octanoate · in 1 record
Experiment against prediction
- 7NA7 chain R against the predicted model Q92847: TM-score 0.94, RMSD 1.80 Å
- 7NA7 chain R against the predicted model Q92847: TM-score 0.94, RMSD 1.80 Å
- 7NA8 chain R against the predicted model Q92847: TM-score 0.93, RMSD 2.01 Å
- 7NA8 chain R against the predicted model Q92847: TM-score 0.93, RMSD 2.01 Å
- 7W2Z chain R against the predicted model Q92847: TM-score 0.92, RMSD 2.32 Å
- 7W2Z chain R against the predicted model Q92847: TM-score 0.92, RMSD 2.32 Å
- 7F83 chain A against the predicted model P0ABE7: TM-score 0.28, RMSD 1.48 Å
- 7F83 chain A against the predicted model P0ABE7: TM-score 0.28, RMSD 1.48 Å
- 6KO5 chain A against the predicted model P0ABE7: TM-score 0.26, RMSD 0.85 Å
- 6KO5 chain A against the predicted model P0ABE7: TM-score 0.26, RMSD 0.85 Å
Elsewhere
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