MolNFT v1 · #181140 · protein
Exendin-4-bound glucagon-like peptide-1 (glp-1) receptor in complex with gs protein
7LLL · Guanine nucleotide-binding protein G(S) subunit alpha…: “Exendin-4-bound glucagon-like peptide-1 (glp-1) receptor in complex with gs protein”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1 #181140 on GenesisL1…
- PDB
- 7LLL
- Type
- protein
- Length
- 1,153 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(S) subunit alpha isoforms short; Guanine…
- UniProt
- P63092, P62873, P59768, P26349, P43220
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 6 distinct chains · 32% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(S) subunit alpha isoforms short | protein | 233 | 33% helix, 16% strand | P63092 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 340 | 7% helix, 40% strand | P62873 |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 58 | 53% helix, 0% strand | P59768 |
| N | NB35 | protein | 128 | 2% helix, 29% strand | — |
| P | Exendin-4 | protein | 28 | 93% helix, 0% strand | P26349 |
| R | Glucagon-like peptide 1 receptor | protein | 366 | 56% helix, 2% strand | P43220 |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1187 | 0.83 | 0.84 | 89 | empty |
| 2 | 888 | 0.74 | 0.78 | 76 | empty |
| 3 | 826 | 0.73 | 0.78 | 88 | empty |
| 4 | 1075 | 0.72 | 0.76 | 63 | empty |
| 5 | 67 | 0.69 | 0.95 | 24 | empty |
Interfaces
7 interfaces between chains.
- B–G · 2221 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 1341 Ų buried · 4 hydrogen bonds · protein-protein
- P–R · 1308 Ų buried · 6 hydrogen bonds · protein-protein
- A–R · 855 Ų buried · 2 hydrogen bonds · protein-protein
- A–N · 835 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 7LLL · Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein · the same entry in another collection · chain R against R, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.98
- P43220 · AlphaFold monomer V2.0 prediction for glucagon-like peptide 1 receptor (P43220) · a predicted model of the same protein · chain R against A, TM-score 0.79
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.75
- P26349 · AlphaFold monomer V2.0 prediction for exendin-4 (P26349) · a predicted model of the same protein · chain P against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P26349
- Every structure of UniProt P43220
- Elsewhere: RCSB PDB 7LLL · PDBe 7LLL · UniProt P63092 · UniProt P62873 · UniProt P59768 · UniProt P26349 · UniProt P43220
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